Title:
MUC1による細胞増殖調節方法
Document Type and Number:
Japanese Patent JP4276432
Kind Code:
B2
Abstract:
The invention features a method of identifying a compound that inhibits (a) the physical interaction (binding) between MUC1 and tumor progressors (e.g., ²-catenin, c-Src, EGF-R, p120 ctn , or PKC´) and/or (b) phosphorylation of MUC1 by tumor progressors with kinase activity (e.g., c-Src, EGF-R, or PKC´). The invention also includes a method of inhibiting an interaction between MUC1 and ²-catenin and a method of inhibiting expression of MUC1 or a tumor progressor in a cell.
Inventors:
Kufe Donald W.
Application Number:
JP2002558794A
Publication Date:
June 10, 2009
Filing Date:
December 26, 2001
Export Citation:
Assignee:
DANA-FARBER CANCER INSTITUTE, INCORPORATED
International Classes:
C12N15/09; A61K31/7052; A61K31/711; A61K45/00; A61K48/00; A61P35/00; A61P35/02; A61P43/00; C07K14/47; C12Q1/02; C12Q1/48; G01N33/15; G01N33/50; G01N33/574; A61K38/00
Other References:
Cancer Res.,1995年,Vol.55,No.18,p.4000-4003
Attorney, Agent or Firm:
Hatsushi Shimizu