Title:
【発明の名称】テクネチウム99mのプロピレンアミンオキシムとの複合体
Document Type and Number:
Japanese Patent JPH0676363
Kind Code:
B2
Abstract:
A family of propylene amine oxime ligands has the formula 2wherein preferably R1 is C1-C4 alkyl or phenyl and each of R, R2, R3 and R4 is H or C1-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the d1- and mesostereoisom- ers, and of the d- and 1-enantiomers, are described. The 1-enantiomer and the d1-stereoisomer of the preferred compound (2, R=R1=R2=CH3, R3=R4=H) show good retention in the brain.
Inventors:
Luis Ruben Canning
David Peter Knowtnick
Rudey Dominique Nayrinx
Ian Michael Piper
David Peter Knowtnick
Rudey Dominique Nayrinx
Ian Michael Piper
Application Number:
JP5350886A
Publication Date:
September 28, 1994
Filing Date:
March 11, 1986
Export Citation:
Assignee:
Amersham Internacional PLC
International Classes:
A61K51/00; A61K51/04; C07C67/00; C07C239/00; C07C251/34; C07C251/38; C07C251/70; C07F13/00; C07K14/00; (IPC1-7): C07C251/38
Domestic Patent References:
| JP6069090A | ||||
| JP61143351A |
Other References:
ＡｃｔａＣｒｙｓｔａｌｌｏｇｒ．，Ｓｅｃｔ．Ｃ：Ｃｒｙｓｔ．Ｓｔｒｕｃｔ．Ｃｏｍｍｕｎ．，Ｃ４０（５），８１３−８１６（１９８４）
Ｉｎｔ．Ｊ．Ｎｕｃｌ．Ｍｅｄ．Ｂｉｏ１．，１２（２），１３３−１３４（１９８５）
ｌｎｏｒｇ．Ｃｈｅｍ．，６（１１），２０４３−２０４６（１９６７）
Ｉｎｔ．Ｊ．Ｎｕｃｌ．Ｍｅｄ．Ｂｉｏ１．，１２（２），１３３−１３４（１９８５）
ｌｎｏｒｇ．Ｃｈｅｍ．，６（１１），２０４３−２０４６（１９６７）
Attorney, Agent or Firm:
Kyozo Yuasa (4 outside)
Next Patent: OPTICAL DISK MEDIA