Title:
ＲＯＲガンマのモジュレーターとしての化合物
Document Type and Number:
Japanese Patent JP2017511357
Kind Code:
A
Abstract:
【課題】ＲＯＲγの活性を変調する新規化合物及び薬物としてのそれらの使用を提供する。【解決手段】本発明はRORγ の変調及びRORγ の変調に関連する疾患の治療に適している式 (I)【化１】（式中、変数は本明細書に定義される）の化合物を含む。また、本発明は式 (I)の化合物の製造方法及びそれらを含む医薬製剤を含む。【選択図】なし
Inventors:
Bakoni Johanna
Brunette stephen richard
Colin Delphine
Hughes Robert Owen
Lisian
Lian Shuang
Sibley robert
Turner Michael Robert
Woolifen
Chang Chian
Brunette stephen richard
Colin Delphine
Hughes Robert Owen
Lisian
Lian Shuang
Sibley robert
Turner Michael Robert
Woolifen
Chang Chian
Application Number:
JP2016562565A
Publication Date:
April 20, 2017
Filing Date:
April 10, 2015
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07D475/00; A61K31/522; A61K31/5377; A61P1/04; A61P3/10; A61P11/02; A61P11/06; A61P13/12; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P37/02; A61P37/06; A61P37/08
Domestic Patent References:
| JP2005507390A | 2005-03-17 | |||
| JP2005507390A | 2005-03-17 |
Foreign References:
| WO2012167046A1 | 2012-12-06 | |||
| WO2009022185A2 | 2009-02-19 | |||
| WO2012167046A1 | 2012-12-06 | |||
| WO2009022185A2 | 2009-02-19 |
Other References:
KHAN, PASHA M. ET AL.: "Small molecule amides as potent ROR-γ selective modulators", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23(2), JPN6017032336, 2013, pages 532-536.
HUGHES, ROBERT O. ET AL.: "Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the cent", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19(15), JPN6017032339, 2009, pages 4092-4096.
KHAN, PASHA M. ET AL.: "Small molecule amides as potent ROR-γ selective modulators", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23(2), JPN6017032336, 2013, pages 532-536.
HUGHES, ROBERT O. ET AL.: "Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the cent", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19(15), JPN6017032339, 2009, pages 4092-4096.
HUGHES, ROBERT O. ET AL.: "Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the cent", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19(15), JPN6017032339, 2009, pages 4092-4096.
KHAN, PASHA M. ET AL.: "Small molecule amides as potent ROR-γ selective modulators", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23(2), JPN6017032336, 2013, pages 532-536.
HUGHES, ROBERT O. ET AL.: "Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the cent", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19(15), JPN6017032339, 2009, pages 4092-4096.
Attorney, Agent or Firm:
Takaki Nishijima
Disciple Maru Ken
Shinichiro Tanaka
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Akizawa
Disciple Maru Ken
Shinichiro Tanaka
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Akizawa