11β-HSD1阻害活性を有する化合物

Japanese Patent JP5223864

B2

The present invention provides compounds having excellent 11²-HSD1 inhibitory activity. A compound represented by the following formula (I): [wherein X 1 represents an oxygen atom, or the formula -(CR 11 R 12 ) p -, etc., Y 1 represents a hydrogen atom, a hydroxyl group, etc., Z 1 represents an oxygen atom or the formula -(NR 14 )-, R 1 represents a hydrogen atom, a halogen atom, a cyano group, a C 1-4 alkyl group, a C 1-4 alkyl group substituted with 1 to 3 halogen atoms, a C 1-4 alkoxy group, a C 1-4 alkoxycarbonyl group, a carboxyl group, a carbamoyl group, or an amino group, and m represents an integer of 1 or 2, and R 2 represents a hydrogen atom or a C 1-4 alkyl group, and n represents an integer of 1 or 2].

JP7257115	Novel sulfonamide intermediate and method for producing silodosin using the same
JPS60181069	PRODUCTION OF 2,3,3-TRIMETHYLCYANOINDOLENINE
WO/2000/012475	INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS

Ryo Suzuki
Mikami Ayako
Hiroaki Tanaka
Hiroshi Fukushima

JP2009520591A

June 26, 2013

June 24, 2008

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Taisho Pharmaceutical Co., Ltd.

C07D209/08; A61K31/404; A61K31/47; A61K31/538; A61K31/5415; A61K31/55; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P5/46; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P17/06; A61P19/10; A61P25/24; A61P25/28; A61P27/06; A61P37/02; A61P43/00; C07D215/08; C07D215/18; C07D215/20; C07D215/48; C07D223/16; C07D241/40; C07D265/36; C07D279/16

WO2006024627A2	2006-03-09
WO2007068330A1	2007-06-21

Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Yamaguchi

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