依存症及び他の精神神経疾患の治療のための組成物及び方法

Japanese Patent JP5415767

B2

The present invention is based, in part, on our discovery that certain types of therapeutic agents can be used in combination to treat a variety of neuropsychiatric and related disorders, including addiction (e.g., to a substance or to an activity) as well as to alleviate some of the symptoms experienced during menopause or associated with the menstrual cycle. Regardless of the precise formulation, the compositions of the invention can include at least one active ingredient that targets the hypothalamo- pituitary-adrenal (HPA) axis and at least one active ingredient that targets the prefrontal cortex. Either or both of these types of agents can be combined with an agent that inhibits activity in the sympathetic nervous system.; Thus, the compositions or combination pharmacotherapies can also include an agent that inhibits a beta-adrenergic receptor or that otherwise acts as an anti-hypertensive or anxiolytic agent.

Geders, Nicholas Yi.

JP2008540272A

February 12, 2014

November 13, 2006

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BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

A61K31/5513; A61K31/444; A61P25/18; A61P25/24; A61P25/30; A61K31/18; A61K31/195; A61K31/343; A61K31/4184; A61K31/425; A61K31/428; A61K31/4535; A61K31/496; A61K31/55; A61K31/7048; A61K38/04; A61K45/00; A61P5/04; A61P5/12; A61P5/42; A61P25/20; A61P25/22; A61P25/32; A61P25/34; A61P25/36; C07D223/26; C07D243/20; C07D261/12; C07D277/82; C07D307/87; C07D403/06; C07D405/06; C07D409/14; C07D471/14; C07H9/04

JP2003506483A

WO2000054766A1
WO2005026126A1
WO2005061508A1
WO2004100992A1

J.Clin.Endocrinol.Metab.,1999年,Vol.84,p.2611-2615
DE SOUZA E B,JOURNAL OF PSYCHIATRIC RESEARCH,英国,1990年,V24 N.SUPPL2,P111-119

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei

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