ガンマ-セクレターゼインヒビターとしてのシクロヘキシルスルホン誘導体

Japanese Patent JP4653485

B2

Compounds of formula I: wherein Ar¹ and Ar² are optionally substituted aryl or heteroaryl, L is a bond, -CH- or -(CHR^a)_n-, and X is SCN, SR¹, S(O)R¹, (CR^aR^b)_mSO₂R¹, SO₂N(R²)₂, SO₂NHCOR¹, SO₂NHN(R²)₂, OSO₂N(R²⁾₂, OS(O)N(R²)₂, OSO₂NHCOR¹, COR⁴, NHCOR¹, NHCO₂R¹, NHCON(R²)₂, NHSO₂R¹ or NHSO₂N(R²)₂, inhibit the processing of APP by gamma secretase, and hence are useful in treatment of Alzheimer's disease.

Cheer Cheer, Ian
Harrison, Tamothy
Keller, Sonia
Oakley, paul joseph
Duncan Edward, Chiyo
Taylor, Martin Lichyard
Williams, Susanna

JP2004540927A

March 16, 2011

September 25, 2003

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Merck Sharp End Dome Limited

C07C317/14; A61K31/10; A61K31/165; A61K31/17; A61K31/18; A61K31/192; A61K31/198; A61K31/215; A61K31/255; A61K31/27; A61K31/277; A61K31/341; A61K31/357; A61K31/36; A61K31/381; A61K31/397; A61K31/40; A61K31/401; A61K31/41; A61K31/4164; A61K31/4196; A61K31/426; A61K31/433; A61K31/439; A61K31/44; A61K31/4402; A61K31/4409; A61K31/4453; A61K31/505; A61K31/5375; A61K31/54; A61P25/28; A61P43/00; C07C317/18; C07C317/20; C07C317/22; C07C317/24; C07C317/26; C07C317/44; C07C331/04; C07D205/04; C07D205/06; C07D207/48; C07D211/96; C07D213/70; C07D213/71; C07D213/89; C07D233/84; C07D239/38; C07D249/08; C07D249/12; C07D257/04; C07D277/20; C07D277/36; C07D285/125; C07D295/08; C07D295/092; C07D295/22; C07D295/26; C07D307/38; C07D307/46; C07D307/52; C07D307/54; C07D307/64; C07D307/68; C07D317/26; C07D317/46; C07D317/62; C07D333/18; C07D333/34; C07D333/48; C07D491/08; C07D285/12

JP2004533428A
JP2005524625A
JP2005504042A
JP2003526603A
JP9169713A

Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura

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