Title:
ファルネシルトランスフェラーゼ阻害性NまたはC結合イミダゾール置換1,8-環付加キノリノン誘導体
Document Type and Number:
Japanese Patent JP4272262
Kind Code:
B2
Abstract:
This invention concerns compounds of formulathe pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; -A- is a bivalent radical of formula; R1 and R2 each independently are hydrogen, hydroxy, halo, cyano, C1-6alkyl, trihalomethyl, trihalomethoxy, C2-6alkenyl, C1-6alkyloxy, hydroxyC1-6alkyloxy, C1-6alkyloxyC1-6alkyloxy, C1-6alkyloxycarbonyl, aminoC1-6alkyloxy, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, Ar, Ar-C1-6alkyl, Ar-oxy, Ar-C1-6alkyloxy; or when on adjacent positions R1 and R2 taken together may form a bivalent radical; R3 and R4 each independently are hydrogen, halo, cyano, C1-6alkyl, C1-6alkyloxy, Ar-oxy, C1-6alkylthio, di(C1-6alkyl)amino, trihalomethyl, trihalomethoxy, or when on adjacent positions R3 and R4 taken together may form a bivalent radical; R5 is an imidazolyl substituted with hydrogen or C1-6alkyl; R6 hydrogen, hydroxy, halo, cyano, optionally substituted C1-6alkyl, C1-6alkyloxycarbonyl or Ar; or a radical of formula -O-R7, -S-R8, -N-R8R9; and Ar is optionally substituted phenyl; having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
Inventors:
Marc Gaston, Benet
Anjibo, Patrick Rene
Lini, Janik Eme Edey
Poncelet, Birjini Sofui
Saint-Jérard-Cialur
Anjibo, Patrick Rene
Lini, Janik Eme Edey
Poncelet, Birjini Sofui
Saint-Jérard-Cialur
Application Number:
JP53919398A
Publication Date:
June 03, 2009
Filing Date:
March 03, 1998
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D215/06; A61K31/47; C07D471/06; A61K31/4704; A61K31/4709; A61K31/4741; A61K31/4745; A61K31/5383; A61P35/00; C07D401/10; C07D401/14; C07D455/04; C07D471/04; C07D491/048; C07D491/052; C07D498/04; C07D498/06
Domestic Patent References:
| JP49041539A | ||||
| JP10511654A | ||||
| JP7507782A | ||||
| JP2223579A | ||||
| JP10511405A | ||||
| JP11514635A |
Other References:
BASS, R.J. et al., J. Agric. Food Chem., 1981年, Vol.29/No.3, p.576-579
MICKELSON, J.W. et al., J. Med. Chem., 1996年, Vol.39/No.23, p.4654-4666
DANKWARDT, J.W. et al., J. Org. Chem., 1995年, Vol.60/NO.8, p.2312-2313
MICKELSON, J.W. et al., J. Med. Chem., 1996年, Vol.39/No.23, p.4654-4666
DANKWARDT, J.W. et al., J. Org. Chem., 1995年, Vol.60/NO.8, p.2312-2313
Attorney, Agent or Firm:
Patent business corporation Odashima patent office
Heigo Odashima
Heigo Odashima