Title:
１８Ｆ標識された葉酸／葉酸代謝拮抗物質同族体
Document Type and Number:
Japanese Patent JP2015516405
Kind Code:
A
Abstract:
本発明は、葉酸構造内のフェニル基が１８Ｆ−ヘテロ環で置換された新規な１８Ｆ−葉酸／葉酸代謝拮抗物質同族体の放射性医薬品、その前駆体、その調製方法、ならびに葉酸受容体を発現させる細胞または細胞集団を診断し、がん、炎症性疾患および自己免疫疾患ならびにそれらの治療をモニターする際にそれを使用することに関する。
Inventors:
Sibri Logger
Moser Rudolph
Muller Christina Magdalena
Amethame Simon Menzer
Betzel Thomas
Grain viola
Moser Rudolph
Muller Christina Magdalena
Amethame Simon Menzer
Betzel Thomas
Grain viola
Application Number:
JP2015510812A
Publication Date:
June 11, 2015
Filing Date:
May 08, 2013
Export Citation:
Assignee:
Merck & Company
International Classes:
C07D475/04; A61K45/00; A61K51/00; A61P29/00; A61P35/00; A61P37/02
Domestic Patent References:
| JP2010526769A | 2010-08-05 |
Other References:
EUGENE, C. R. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 14, no. 2, JPN7016004052, 1971, pages 125 - 130, ISSN: 0003474273
EUGENE, C. R. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 15, no. 12, JPN7016004053, 1972, pages 1310 - 1312, ISSN: 0003474274
EUGENE, C. R. ET AL., JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 11, no. 4, JPN7016004054, 1974, pages 547 - 550, ISSN: 0003474275
NAKAHARA, Y. ET AL., JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 12, no. 5, JPN7016004055, 1975, pages 1073 - 1074, ISSN: 0003474276
LYNN, S. G. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, JPN7016004056, 1999, pages 75 - 78, ISSN: 0003474277
EUGENE, C. R. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 15, no. 12, JPN7016004053, 1972, pages 1310 - 1312, ISSN: 0003474274
EUGENE, C. R. ET AL., JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 11, no. 4, JPN7016004054, 1974, pages 547 - 550, ISSN: 0003474275
NAKAHARA, Y. ET AL., JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 12, no. 5, JPN7016004055, 1975, pages 1073 - 1074, ISSN: 0003474276
LYNN, S. G. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, JPN7016004056, 1999, pages 75 - 78, ISSN: 0003474277
Attorney, Agent or Firm:
Mitsufumi Esaki
Blacksmith
Katsunori Uenishi
Ichiro Torayama
Blacksmith
Katsunori Uenishi
Ichiro Torayama