Title:
クロピドグレル硫酸水素塩の結晶形態Iを製造する方法
Document Type and Number:
Japanese Patent JP2006502238
Kind Code:
A
Abstract:
A method for manufacturing hydrogen sulphate (alpha S) of the alpha-(2-chlorophenyl)-6,7dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester (clopidogrel hydrogen sulphate) of formula I, in crystalline Form I, wherein the compound of formula is separated out of a solution of clopidogrel in the form of the free base or salt in a solvent selected from the series of primary, secondary or tertiary C1-C5 alcohols, their esters with C1-C4 carboxylic acids, or optionally of mixtures thereof.
Inventors:
Wevelka Miroslav
Vodny Stefan
Veverkov Eva
Hajischek Joseph
Stepan Kowa Hana
Vodny Stefan
Veverkov Eva
Hajischek Joseph
Stepan Kowa Hana
Application Number:
JP2004569700A
Publication Date:
January 19, 2006
Filing Date:
August 26, 2003
Export Citation:
Assignee:
Zentiva, A.S.
International Classes:
C07D495/04; C07D515/02; A61P7/02; B01D9/02; A61K31/4365
Domestic Patent References:
| JPS63203684A | 1988-08-23 | |||
| JP2002518399A | 2002-06-25 |
Foreign References:
| WO2003051362A2 | 2003-06-26 |
Attorney, Agent or Firm:
Tamotsu Otani