【発明の名称】半合成法及び新規の化合物

Title:

【発明の名称】半合成法及び新規の化合物

Document Type and Number:

Japanese Patent JP2002544280

Kind Code:

A

Abstract:

Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from -H, -OH or -OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both -H ozone is -H and the other is -OH, -OCH3 or -OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from -H or -OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.

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Inventors:

Carmen Cuevas
Marta Perez
Andres Frances
Carolina Fernandez
Jose Luis Chicharo
Pilar Gallego
Maria Sarsuelo
Fernando de la Carge
Ignacio Manzanares

Application Number:

JP2000618279A

Publication Date:

December 24, 2002

Filing Date:

May 15, 2000

Export Citation:

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Assignee:

Pharma Mar Sociedad Anonima

International Classes:

A61K31/4995; A61K35/00; A61P31/04; A61P35/00; C07D221/00; C07D241/00; C07D471/18; C07D291/00; C07D317/00; C07D471/22; C07D487/18; C07D491/22; C07D515/00; C07D515/22; C07D; (IPC1-7): C07D487/18; A61K31/4995; A61P31/04; A61P35/00; C07D491/22; C07D515/22

Attorney, Agent or Firm:

Masatake Shiga (7 outside)

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