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Title:
【発明の名称】濃度改善がなされた血液または血漿成分溶液の調製方法
Document Type and Number:
Japanese Patent JP2003512908
Kind Code:
A
Abstract:
A method for separating a blood component, e.g., fibrin monomer, from blood or plasma. The method utilizes a container with a reaction chamber for receiving the plasma. The reaction chamber is defined by a wall and an agent is supplied to the reaction chamber for converting the fibrinogen content of the plasma into a non-cross-linked fibrin polymer. The method also utilizes a device for centrifuging the reaction chamber with the plasma and the agent to a degree sufficient for separating the non-cross-linked fibrin polymer from the plasma, for depositing the polymer on the outer wall of the reaction chamber, and for expelling the remaining plasma from the reaction chamber. A solvent is supplied to the reaction chamber for dissolving the non-cross-linked fibrin polymer. The solvent is supplied to the reaction chamber in a first amount for dissolving the non-cross-linked fibrin polymer which is less than the total amount of solvent for dissolving the polymer. The remaining solvent is supplied to the reaction chamber in one or more portions to flush the reaction chamber and other portions of the device and recover additional non-cross-linked fibrin polymer.

Inventors:
Gautam Busker
Glen A. Jergensen
Application Number:
JP2001534488A
Publication Date:
April 08, 2003
Filing Date:
September 29, 2000
Export Citation:
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Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K35/14; A61M1/02; A61M1/36; B01D21/26; B04B1/02; C07K14/75; (IPC1-7): A61M1/02; A61K35/14; B04B1/02
Domestic Patent References:
JPS5465941U1979-05-10
JPS4894675A1973-12-05
Foreign References:
WO1998030887A11998-07-16
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)