Title:
A manufacturing method of optical activity tetrahydroquinoline
Document Type and Number:
Japanese Patent JP6073223
Kind Code:
B2
Abstract:
Provided are a novel chiral iridium(III) complex; and a method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines from 2-substituted-quinolines with the use of the chiral iridium(III) complex through a more economical and easy production process. The disclosed method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines comprises reducing a quinoline compound represented by formula [I]:
in the presence of a hydrogen donor compound and an iridium(III) complex having a chiral prolinamide compound as a ligand to give an optically active 2-substituted-1,2,3,4-tetrahydroquinoline represented by formula [II]:
Inventors:
Maeda Sadayuki
Tatsunori Sato
Yasuhiko Kawano
Miyawaki Toshio
Tatsunori Sato
Yasuhiko Kawano
Miyawaki Toshio
Application Number:
JP2013524698A
Publication Date:
February 01, 2017
Filing Date:
July 13, 2012
Export Citation:
Assignee:
Hamari Pharmaceutical Co., Ltd.
International Classes:
C07D215/06; B01J31/22; B01J37/04; C07B53/00; C07B61/00; C07D215/18; C07D215/20; C07F17/00
Foreign References:
| WO2009005024A1 |
Other References:
ORGANIC LETTERS,2008年,10(22),pp.5265-5268
J. AM. CHEM. SOC.,2003年,125(35),pp.10536-10537
Z. anorg. allg. Chem.,1997年,623,pp.1903-1911
J. AM. CHEM. SOC.,2003年,125(35),pp.10536-10537
Z. anorg. allg. Chem.,1997年,623,pp.1903-1911
Attorney, Agent or Firm:
Ryu Iwatani