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Title:
【発明の名称】カテコール誘導体を有効成分とする医薬組成物
Document Type and Number:
Japanese Patent JPH085781
Kind Code:
B2
Abstract:
Pharmacologically active catechol derivatives of formula I I wherein R1 and R2 independently comprise hydrogen, alkyl, acyl, optionally substituted aroyl, lower alkylsulfonyl or alkylcabamoyl or taken together form a lower alkylidene or cycloalkylidene, X comprises an electronegative substituent such as halogen, nitro, cyano, lower alkylsulfonyl, sulfonamido, aldehyde, caboxyl or trifluoromethyl and R3 comprises hydrogen, halogen, hydroxy alkyl, amino, nitro, cyano, trifluoromethyl, lower alkylsulfonyl, sulfonamide, aldehyde, alkyl carbonyl, aralkylidene carbonyl or carboxyl or a group selected from wherein R4 comprises hydrogen, alkyl, cyano, carboxyl or acyl and R5 comprises hydrogen, cyano, carboxyl, alkoxycarbonyl, carboxyalkenyl, nitro, acyl, optionally substituted aroyl or heteroaroyl, hydroxyalkyl or carboxyalkyl or R4 and R5 together form a five to seven membered substituted cycloalkanone ring; -(CO)n(CH2)m-COR wherein n is 0-1 and m is 0-7 and R comprises hydroxy, alkyl, carboxyalkyl, optionally substituted alkene, alkoxy or optionally substituted amino; wherein R8 and R9 independently comprise hydrogen or one of the following optionally substituted groups; alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, or together form an optionally substituted piperidyl group; -NH-CO-R10 wherein R10 comprises a substituted alkyl group.

Inventors:
Reijo Johannes Beckström
Kalebi Ebert Hainora
Erki Yuhani Honkanen
Seppo-Kalebi-Kakora
Pekka Juhani Kairisaro
Inge-Britt Yubonne Linden
Pekka Topias Menniste
Erki Ahlne Orabi Nisinen
Pliers Pocht
Aino Kirikki Pippuri
Yarmo Johan Pistinen
Application Number:
JP30138887A
Publication Date:
January 24, 1996
Filing Date:
November 27, 1987
Export Citation:
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Assignee:
Orion-Yuhichume Oyu
International Classes:
A61K31/00; A61K31/04; A61K31/045; A61K31/047; A61K31/05; A61K31/06; A61K31/075; A61K31/085; A61K31/11; A61K31/12; A61K31/13; A61K31/135; A61K31/165; A61K31/19; A61K31/215; A61K31/235; A61K31/275; A61K31/33; C07C27/00; A61K31/335; A61K31/357; A61K31/36; A61K31/395; A61K31/40; A61K31/44; A61K31/4409; A61K31/4418; A61K31/443; A61K31/445; A61K31/4468; A61K31/451; A61K31/47; A61K31/495; A61P9/12; A61P25/00; A61P25/24; A61P25/26; A61P25/28; A61P43/00; C07C39/08; C07C39/24; C07C39/26; C07C39/373; C07C43/20; C07C43/23; C07C45/00; C07C45/56; C07C45/67; C07C45/74; C07C47/52; C07C47/565; C07C47/575; C07C49/20; C07C49/245; C07C49/747; C07C49/76; C07C49/83; C07C49/835; C07C49/84; C07C59/40; C07C59/52; C07C59/56; C07C59/64; C07C59/68; C07C59/90; C07C65/00; C07C65/03; C07C65/21; C07C67/00; C07C69/017; C07C69/035; C07C69/73; C07C69/76; C07C205/20; C07C205/22; C07C205/23; C07C205/26; C07C205/34; C07C205/37; C07C205/43; C07C205/45; C07C205/56; C07C205/57; C07C213/00; C07C231/00; C07C233/00; C07C233/12; C07C235/44; C07C235/54; C07C235/66; C07C239/00; C07C253/00; C07C255/37; C07C255/53; C07C301/00; C07C309/65; C07C311/15; C07C317/22; C07D207/325; C07D207/333; C07D211/14; C07D211/22; C07D211/30; C07D211/32; C07D211/58; C07D213/30; C07D215/14; C07D295/08; C07D295/13; C07D295/18; C07D295/185; C07D317/52; C07D317/62; C07D319/24; C07D405/04; C07D405/06; C07D207/32; C07C; (IPC1-7): A61K31/12; A61K31/165; A61K31/19; A61K31/215; A61K31/36; A61K31/40; A61K31/44; A61K31/445; A61K31/47
Other References:
【文献】Nature(London),Vol.228No.5269(1971)p.358
Attorney, Agent or Firm:
Sota Asahina (1 person outside)