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Title:
A medicine constituent for preventing, diagnosing or treating cancer or blood vessel new associated diseases containing an anti-VEGF antibody and it
Document Type and Number:
Japanese Patent JP6328231
Kind Code:
B2
Abstract:
The present invention relates to: a novel anti-vascular endothelial growth factor (VEGF) antibody having a strong binding affinity for VEGF and capable of inhibiting in vivo tumor growth; and a composition for the treatment of cancer, containing the same. The antibody of the present invention shows a remarkable binding property to human and mouse VEGF, suppresses the proliferation and permeability of a human umbilical vein endothelial cell (HUVEC) and inhibits tumor growth, and thus can be useful as an antibody for the treatment of cancer.

Inventors:
Do Hyun Mi
Kim Byung Moon
Kim Chae Young
Lee Sung Hee
Kim Dong Hyun
Kim Yu Jin
Lee Dong-seop
Han Kyung Mi
Song Dong Sup
Jung Eun Yi
Lee Jin Suk
Song U Jin
Hwang Gusan
Application Number:
JP2016516455A
Publication Date:
May 23, 2018
Filing Date:
May 30, 2014
Export Citation:
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Assignee:
DONG-A SOCIO HOLDINGS CO., LTD.
Dong-A ST Co., Ltd.
International Classes:
C07K16/22; A61K39/395; A61K45/00; A61P9/10; A61P27/02; A61P35/00; A61P43/00; C07K16/46; C12N5/10; C12N15/09; G01N33/574
Domestic Patent References:
JP2011046732A
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Fumio Inai
Manami Sasakura