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Patent Searching and Data


Title:
The meld rum acid as a HNO donor replaced by hydroxylamine, barbituric acid, and the derivative of Pyrazolone
Document Type and Number:
Japanese Patent JP6177246
Kind Code:
B2
Abstract:
The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

Inventors:
ガスリー,ダリル・エイ
トスカーノ,ジョン・ピー
Application Number:
JP2014537151A
Publication Date:
August 09, 2017
Filing Date:
October 16, 2012
Export Citation:
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Assignee:
ザ・ジョンズ・ホプキンス・ユニバーシティ
International Classes:
C07D231/46; A61K31/357; A61K31/4152; A61K31/515; A61P9/00; A61P9/10; A61P9/12; A61P35/00; A61P43/00; C07D239/62; C07D319/06
Domestic Patent References:
JP2011523404A
Foreign References:
Attorney, Agent or Firm:
小野 新次郎
小林 泰
竹内 茂雄
山本 修
寺地 拓己