Title:
マクロライドならびにそれらの調製および使用の方法
Document Type and Number:
Japanese Patent JP6437523
Kind Code:
B2
Abstract:
Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.
Inventors:
Myers, Andrew, Gee.
Saple, Ian, Bus
Chan, Tzuyan
Saple, Ian, Bus
Chan, Tzuyan
Application Number:
JP2016506660A
Publication Date:
December 12, 2018
Filing Date:
April 04, 2014
Export Citation:
Assignee:
PRESIDENT AND FELLOWS OFHARVARD COLLEGE
International Classes:
C07H17/08; A61K31/7052; A61P11/00; A61P29/00; A61P31/00; A61P31/04; A61P33/00
Domestic Patent References:
| JP2003507487A | ||||
| JP2002542254A | ||||
| JP2012506872A |
Foreign References:
| WO1999000125A1 | ||||
| WO2012051126A2 | ||||
| US6262030 | ||||
| US20060100164 | ||||
| US20090209547 | ||||
| WO2012034058A1 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa