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Title:
正常細胞を化学療法剤の細胞毒性から保護するための方法
Document Type and Number:
Japanese Patent JP4780885
Kind Code:
B2
Abstract:
Pre-treatment with alpha , beta unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the alpha , beta unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.

Inventors:
Stephen C. Cosenza
M.V.Ramana Lady
E. Prem Kumar Lady
Application Number:
JP2001529435A
Publication Date:
September 28, 2011
Filing Date:
October 11, 2000
Export Citation:
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Assignee:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
International Classes:
A61K31/10; A61K45/00; A61K31/12; A61K31/136; A61K31/192; A61K31/337; A61K31/341; A61K31/35; A61K31/381; A61K31/40; A61K31/426; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4745; A61K31/475; A61K31/7048; A61K45/06; A61P35/00; A61P43/00; C07C317/10; C07C317/14; C07C317/18; C07C317/44
Domestic Patent References:
JPH0517429A1993-01-26
Foreign References:
WO1996040629A11996-12-19
WO1998006391A11998-02-19
WO1999018068A11999-04-15
Attorney, Agent or Firm:
Axis International Patent Business Corporation
Motohiro Kurauchi
Hiroshi Kazama



 
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