Title:
アゴメラチンの新規な結晶形態III、その製造方法、およびそれを含有する薬学的組成物
Document Type and Number:
Japanese Patent JP4580370
Kind Code:
B2
Abstract:
Crystalline form III of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide is new. The compound is confirmed by powder X-ray diffraction pattern as given in the specification. An independent claim is included for preparation of the crystalline form III of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide involves: heating agomelatine at 110[deg]C until fully melted, and then slowly cooled until recrystallization occurs. ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Gastrointestinal-Gen; CNS-Gen; Cardiovascular-Gen.; Neuroleptic; Muscular-Gen.; Immunomodulator; Eating-Disorder-Gen.; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Neuroprotective; Dermatological; Antimigraine; Cerebroprotective; Endocrine-Gen.; Cytostatic; Analgesic; Contraceptive. MECHANISM OF ACTION : Melatoninergic system receptor agonist; 5-HT(hydroxytryptamine)-2C receptor antagonist. No biological data given.
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Inventors:
Gerard Coquerel
Julie Renor
Jean-Claude Svy
Julie Renor
Jean-Claude Svy
Application Number:
JP2006211620A
Publication Date:
November 10, 2010
Filing Date:
August 03, 2006
Export Citation:
Assignee:
Réra Bora Toir Servier
International Classes:
C07C233/18; A61K31/165; A61P1/00; A61P3/04; A61P3/10; A61P5/06; A61P9/00; A61P15/08; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P35/00; A61P37/00; A61P43/00; C07C231/24
Domestic Patent References:
| JP7048331A |
Other References:
日本化学会編,実験化学講座1 基本操作I,丸善株式会社,1990年11月 5日,第4版,203-213頁
Journal of Medicinal Chemistry,1994年,Vol.37,p.3231-3239
Journal of Medicinal Chemistry,1994年,Vol.37,p.3231-3239
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda