【発明の名称】メタロプロテアーゼ阻害剤としての新規なマクロ環状化合物

Title:

【発明の名称】メタロプロテアーゼ阻害剤としての新規なマクロ環状化合物

Document Type and Number:

Japanese Patent JP2000502050

Kind Code:

A

Abstract:

This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.

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Inventors:

Chiyu, Chiyu-Beiou
Robert Chowani, Robert Joseph
Karl Peter Dechitsuko
William Frank, Degrad
Hey, Shao Why
Karl Nicholas
The Eicobsun, Irina Seapora
Ronald Lewis, Magourda
Earner, Elizabeth Katherine
Deyuan, Jin Woo
Nelson, David The Ray

Application Number:

JP51911997A

Publication Date:

February 22, 2000

Filing Date:

November 13, 1996

Export Citation:

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Assignee:

The DuPont Merck Pharmaceuticals Company

International Classes:

A61K31/00; A61K31/395; A61K31/40; A61K31/407; A61K31/415; A61K31/416; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/42; A61K31/422; A61K31/425; A61K31/427; A61K31/44; A61K31/4427; A61K31/445; A61K31/4465; A61K31/4523; A61K31/495; A61K31/496; A61K31/535; A61K31/5375; A61K31/5377; A61K38/00; A61K49/00; A61P29/00; C07D245/02; C07D255/02; C07D267/00; C07D273/02; C12Q1/37; C07D291/02; C07D291/08; C07D401/12; C07D403/04; C07D403/12; C07D413/12; C07D417/12; C07D419/12; C07D498/08; C07D521/00; C07K5/02; C07K5/06; C07K5/062; C07K5/065; C07K5/068; C07K5/078; (IPC1-7): C07D245/02; A61P29/00; A61K31/395; A61K31/407; A61K31/416; A61K31/4178; A61K31/4184; A61K31/422; A61K31/427; A61K31/4427; A61K31/4523; A61K31/496; A61K31/5377; A61K38/00; A61K49/00; C07D267/00; C07D273/02; C07D291/08; C07D401/12; C07D403/04; C07D403/12; C07D413/12; C07D417/12; C07D419/12; C07D498/08; C07K5/02; C07K5/062; C07K5/065; C07K5/068; C12Q1/37

Attorney, Agent or Firm:

Chika Takagi (1 person outside)

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