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Title:
The new molecular entity which serves as thrombolysis, free radical capture, and the targeting function to a thrombus, and its manufacturing method and use
Document Type and Number:
Japanese Patent JP6212123
Kind Code:
B2
Abstract:
The present invention discloses a novel compound with effects of thrombolysis, free radical scavenging and thrombus-targeting, as well as a preparation method and use thereof. The compound is a ternary conjugate formed by conjugating a thrombolytic peptide, a free radical scavenger and a thrombus-targeting/antithrombotic peptide together via a linking arm. The present invention also discloses a pharmaceutical composition containing the compounds, wherein the compounds form a nanospherical structure.

Inventors:
Peng Master Odd
Zhao Ming
Jean Snow
Application Number:
JP2015530267A
Publication Date:
October 11, 2017
Filing Date:
March 15, 2013
Export Citation:
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Assignee:
Shanghai Lumosa Therapeutics Company Limited
International Classes:
C07K7/06; A61K38/08; A61K47/18; A61K47/50; A61P7/02; A61P9/00; A61P9/10; A61P39/06; C07K1/02
Foreign References:
CN101591376A
CN1978462A
CN1490328A
CN102477072A
CN102485746A
CN101190940A
CN101085806A
Other References:
Journal of Capital University of Medical Sciences,2005年,26,p.42
Journal of Chinese Pharmaceutical Sciences ,1996年,5(4),p.174-176
Attorney, Agent or Firm:
Hayashi Ichiyoshi
Tetsuo Shiba
Iwaike Mitsuru