The percutaneous absorption tablet containing Rotigotine (Transdermalcompositioncomprisingrotigotine)

Japanese Patent JP6180520

B2

The present invention relates to a method for preventing the formation of rotigotine crystals. More particularly, the present invention relates to a method for preventing the precipitation of rotigotine crystals, comprising a step of mixing rotigotine and one or more crystallization prevention agents selected from the group consisting of fatty alcohols, fatty acids, fatty acid esters, fatty acid amides, and the derivatives thereof, and to a transdermally absorbable preparation that comprises rotigotine and crystallization prevention agents. The method and system of the present invention enable the prevention of the precipitation of rotigotine to thus increase stability during long-term storage, and therefore can be effectively applied to the manufacture of rotigotine-containing patches or the like.

WO/1999/057117	INDOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF MALIGNANT AND OTHER DISEASES CAUSED BY PATHOLOGICAL CELL PROLIFERATION
WO/2006/090930	NOVEL COMBINATIONAL USE OF SULFONAMIDE COMPOUND
JPH02231464	INDANE OXYACETATE DERIVATIVE

Kim, He-Min
Fan Yung-Yoon
Yun, Won-no
Park, Yojin
Oh, Jun-Gyo
Im john-sop
Kim, Hun-tech

JP2015520068A

August 16, 2017

July 05, 2013

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SK Chemicals Company Limited

A61K31/381; A61K9/70; A61K47/10; A61K47/12; A61K47/32; A61K47/34; A61P25/16; A61P43/00

JP2005528413A
JP2005535687A
JP2010532390A
JP2009029768A
JP2008266198A

WO2008044336A1
WO1997037659A1
WO2009139411A1

Kihei Watanabe
Okano Isao
Yuko Tanaka
Narumi Morishima
Shinichi Nakayama
Tetsuya Imai
Ikutomi Seiichi
Koji Hirayama
Shinichiro Yamazaki

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