Title:
ベンゾチアゼピン誘導体の製造方法
Document Type and Number:
Japanese Patent JPH06768
Kind Code:
B2
Abstract:
The present invention relates to a process for the preparation of benzothiazepin derivatives of general formula Iwherein R stands for hydrogen and acetyl or of acid addition salts thereof in which a corresponding compound of general formula IIin which R has the same meaning as above is rected with 2-(dimethylamino)-ethyl chloride in a biphasic system of water and a non-combustible aliphatic polychlorinated hydrocarbon solvent in the presence of calcium hydroxide or of barium hydroxide. The process is advantageously performed at a temperature between 15° and the refluxing temperature of the aliphatic polychlorinated hydrocarbon solvent. The process is optionally performed in the presence of a suitable quaternary ammonium halide. In the process the amount of calcium hydroxide or barium hydroxide is advantageously 1-3 moles per 1 mole of the compound of general formula II, the amount of aliphatic polychlorinated hydrocarbon solvent is advantageously 15-40 ml and that of water 3-10 ml per g of the compound of general formula II and the ratio aliphatic chlorinated hydrocarbon solvent:water is advantageously 2:1 to 10:1.
Inventors:
HAIMU SHIMONOBITSUCHI
TEODORU HOFUMAN
SABARU SATSUSON
TEODORU HOFUMAN
SABARU SATSUSON
Application Number:
JP7915685A
Publication Date:
January 05, 1994
Filing Date:
April 12, 1985
Export Citation:
Assignee:
ABIC LTD
International Classes:
C07D281/10; (IPC1-7): C07D281/10
Domestic Patent References:
| JPS5829779A | ||||
| JPS5899471A |
Foreign References:
| GB1236467A |
Attorney, Agent or Firm:
青山 葆 （外１名）
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