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Title:
【発明の名称】プレニル蛋白トランスフェラーゼ阻害薬
Document Type and Number:
Japanese Patent JP2002519427
Kind Code:
A
Abstract:
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

Inventors:
Dainsmore, Christopher Jay
Bell, Ian Em
Vishyoa, Douglas Sea
Williams, Theresa M
Application Number:
JP2000558104A
Publication Date:
July 02, 2002
Filing Date:
June 29, 1999
Export Citation:
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Assignee:
Merck End-Campany Inc.
International Classes:
C07D498/08; A61K31/337; A61K31/415; A61K31/4188; A61P9/00; A61P9/10; A61P13/12; A61P27/02; A61P31/10; A61P31/12; A61P31/14; A61P35/00; A61P43/00; C07D498/04; C07D515/08; (IPC1-7): C07D498/08; A61K31/337; A61K31/4188; A61P9/00; A61P9/10; A61P13/12; A61P27/02; A61P31/10; A61P31/12; A61P31/14; A61P35/00; A61P43/00; C07D515/08
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)