Title:
抗菌薬としてのキノロン誘導体
Document Type and Number:
Japanese Patent JP2017523213
Kind Code:
A
Abstract:
本発明は、医薬品化学の分野にあり、細菌ギラーゼを阻害する化合物およびその医薬組成物に関する。本化合物は、細菌ギラーゼ活性および細菌感染症の阻害剤として有用であり、本明細書にさらに記載される式（Ｉ）の構造を有する。本発明は、さらに、式（Ｉ）の化合物を含む医薬組成物、および本化合物および本組成物を使用して細菌感染症を処置する方法を提供する。
Inventors:
Javier de Vincent, Fidalgo
Hey, high inn
Fu, Chen
Jean, Gigan
Lee, Shaolin
Lou, Phai Chao
Mergo, Warsen
Mattonic, daniel
Wreck, Folkart
Livkin, Alexie
Skepper, Colin Keith
Wang, Xiao Jin Michael
Char, Jinhwa
Shu, Young Jin
Hey, high inn
Fu, Chen
Jean, Gigan
Lee, Shaolin
Lou, Phai Chao
Mergo, Warsen
Mattonic, daniel
Wreck, Folkart
Livkin, Alexie
Skepper, Colin Keith
Wang, Xiao Jin Michael
Char, Jinhwa
Shu, Young Jin
Application Number:
JP2017506320A
Publication Date:
August 17, 2017
Filing Date:
August 03, 2015
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D215/38; A61K31/4709; A61K31/496; A61K31/5377; A61K31/5386; A61K45/00; A61P31/04; A61P43/00; C07D401/04; C07D401/14; C07D405/14; C07D413/14; C07D419/14; C07D471/04; C07D471/10; C07D487/10; C07D498/10
Domestic Patent References:
| JPS60209567A | 1985-10-22 | |||
| JPS61165383A | 1986-07-26 | |||
| JPH09255659A | 1997-09-30 | |||
| JP2003508387A | 2003-03-04 | |||
| JP2003012667A | 2003-01-15 |
Foreign References:
| WO2014171527A1 | 2014-10-23 | |||
| WO2008069242A1 | 2008-06-12 | |||
| US5310723A | 1994-05-10 | |||
| US4959363A | 1990-09-25 | |||
| WO2006137485A1 | 2006-12-28 |
Other References:
YAMADA S: "FLUORESCENT RETINOID X RECEPTOR LIGANDS FOR FLUORESCENCE POLARIZATION ASSAY", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. VOL:20, NR:17, JPN5017006237, September 2010 (2010-09-01), NL, pages 5143 - 5146, ISSN: 0004164014
H. N. HARISHKUMAR, ET AL: "Aqueous Synthesis of N-Phenyl/alkyl-2-quinolinone-3-carboxylic Acids from Coumarin-3-carboxylic Acid", SYNTHETIC COMMUNICATIONS, vol. 40, (22), JPN6019015830, 2010, pages 3281 - 3289, ISSN: 0004164015
H. N. HARISHKUMAR, ET AL: "Aqueous Synthesis of N-Phenyl/alkyl-2-quinolinone-3-carboxylic Acids from Coumarin-3-carboxylic Acid", SYNTHETIC COMMUNICATIONS, vol. 40, (22), JPN6019015830, 2010, pages 3281 - 3289, ISSN: 0004164015
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Uetake Yukiko
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Uetake Yukiko
Yasuhito Suzuki