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Title:
【発明の名称】複数の共刺激分子を発現する組換えベクターおよびその利用
Document Type and Number:
Japanese Patent JP2002531133
Kind Code:
A
Abstract:
The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4<+> and CD8<+> T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.

Inventors:
Shrom, jeffrey
Hodge, james
Panicali, Dennis
Application Number:
JP2000586927A
Publication Date:
September 24, 2002
Filing Date:
November 12, 1999
Export Citation:
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Assignee:
THE UNITED STATES OF AMERICA
Cerion Biologics Corporation
International Classes:
G01N33/53; A61K35/74; A61K35/76; A61K38/00; A61K39/00; A61K39/12; A61K39/125; A61K39/21; A61K39/235; A61K39/245; A61K39/275; A61K39/29; A61K48/00; A61P1/04; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/02; A61P37/06; C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12N15/02; C12N15/863; C12Q1/02; A61K35/12; (IPC1-7): C12N15/02; A61K35/12; A61K35/74; A61K35/76; A61K38/00; A61K39/00; A61K39/12; A61K39/125; A61K39/21; A61K39/235; A61K39/245; A61K39/275; A61K39/29; A61K48/00; A61P1/04; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/02; A61P37/06; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12Q1/02; G01N33/53
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)