Title:
The solid tablet containing the miniaturization crystal of 2- [3-cyano 4- (2-methyl propoxy) phenyl] -4-methylthiazole 5-carboxylic acid, its fine powder ghost, and these
Document Type and Number:
Japanese Patent JP6283371
Kind Code:
B2
Abstract:
[Problem] To provide compact C crystals of febuxostat, a micronisate of the febuxostat C crystals, and a solid preparation that contains the micronisate, easily disintegrates and is highly stable. [Solution] A solid preparation is produced by crystallizing febuxostat from acetonitrile to obtain compact C crystals of febuxostat, pulverizing the compact C crystals by airflow milling or wet milling, and including the compact C crystals of febuxostat or the micronisate thereof as an active ingredient.
Inventors:
Tendo On
Nobutaka Mochizuki
Hiroshi Komatsu
Yutaka Nomura
Yasushi Hatada
Eiji Kumagai
Tsuyoshi Yanagimoto
Nobutaka Mochizuki
Hiroshi Komatsu
Yutaka Nomura
Yasushi Hatada
Eiji Kumagai
Tsuyoshi Yanagimoto
Application Number:
JP2015544611A
Publication Date:
February 21, 2018
Filing Date:
October 22, 2014
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO.,LTD.
International Classes:
C07D277/56
Foreign References:
| WO2003082279A1 | ||||
| WO1999065885A1 |
Other References:
Industrial & Engineering Chemistry Research,2012年,Vol. 51, No. 39,pp. 12814-12820
川上 亘作監修,難水溶性薬物の物性評価と製剤設計の新展開,2010年 1月29日,第1刷,第141~150頁
川上 亘作監修,難水溶性薬物の物性評価と製剤設計の新展開,2010年 1月29日,第1刷,第141~150頁
Attorney, Agent or Firm:
Sumio Tanai
Masayuki Ogura
Makiko Otsuki
Chikusa Shinichi
Satoshi Hashimoto
Masayuki Ogura
Makiko Otsuki
Chikusa Shinichi
Satoshi Hashimoto