Title:
安定な成長ホルモン液体製剤
Document Type and Number:
Japanese Patent JP2007516274
Kind Code:
A
Abstract:
The present invention is directed to stable liquid growth hormone formulations that remain stable after physical agitation, and after exposure to one or more freeze-thaw events. Formulations of the present invention can be stored long term at a variety of temperatures, even frozen. In the present invention, a combination of buffer and stabilizing agents, including a non-ionic surfactant (e.g., polysorbate 20), a polymer stabilizer (e.g., polyethylene glycol), and other optional stabilizers combine to provide unexpected stability to aqueous formulations of a growth hormone (e.g., human growth hormone).
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Inventors:
Advite Baduker
Sandeep Nema
Manpuri Wadduwa
Sandeep Nema
Manpuri Wadduwa
Application Number:
JP2006546366A
Publication Date:
June 21, 2007
Filing Date:
December 13, 2004
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
A61K38/27; A61K9/00; A61K47/00; A61K47/02; A61K47/10; A61K47/12; A61K47/18; A61K47/22; A61K47/26; A61K47/34; A61P5/06; A61P19/10; A61P43/00
Domestic Patent References:
| JP2000504696A | 2000-04-18 | |||
| JP2001517635A | 2001-10-09 | |||
| JPH07509719A | 1995-10-26 | |||
| JP2000508665A | 2000-07-11 |
Foreign References:
| WO2002017957A1 | 2002-03-07 | |||
| WO1997014430A1 | 1997-04-24 | |||
| US5358708A | 1994-10-25 | |||
| US5272135A | 1993-12-21 |
Attorney, Agent or Firm:
Yoshinobu Murofushi