Title:
糖鎖関連遺伝子、およびその利用
Document Type and Number:
Japanese Patent JP5481426
Kind Code:
B2
Abstract:
As a result of dedicated studies, the present inventors succeeded in discovering, for the first time, that fibrogenesis could be suppressed at the physiological tissue level by inhibiting sulfation at position 4 or 6 of GalNAc, which is a sugar that constitutes sugar chains. Furthermore, the present inventors conducted studies using various disease model animals, and as a result, successfully demonstrated that inhibitors of sulfation at position 4 or 6 of GalNAc had therapeutic effects on diseases caused by tissue fibrogenesis (tissue fibrogenic disorders).
Inventors:
Hiroyuki Yoneyama
Jun Koyama
Fujii Shoto
Jun Koyama
Fujii Shoto
Application Number:
JP2011110047A
Publication Date:
April 23, 2014
Filing Date:
May 17, 2011
Export Citation:
Assignee:
Steric Institute for Regenerative Medicine
International Classes:
A61K48/00; A61K31/7105; A61P1/00; A61P1/18; A61P7/00; A61P9/00; A61P11/00; A61P17/00; A61P19/04; A61P25/28; A61P27/02; A61P43/00; C12Q1/48; C12Q1/68; G01N33/15; G01N33/50
Domestic Patent References:
| JP2004504262A |
Foreign References:
| WO2007049424A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto