Title:
【発明の名称】0▲上2▼,2′‐アンヒドロ‐1‐(β‐D‐アラビノフラノシル)チミンの製造方法
Document Type and Number:
Japanese Patent JPH075626
Kind Code:
B2
Abstract:
In the disclosed process, an O<2>,2 min anhydro-1-( beta -D-arabinofuranosyl)thymine is formed by condensing a 2-amino- beta -arabinofurano[1 min ,2 min :4,5,]-2-oxazoline with a compound of the formula wherein R1 is C1-C4 alkyl; X is halogen or OR2, wherein R2 is H, C1-C4 alkyl or phenyl; in the presence of a suitable solvent at about 0 DEG C to about 150 DEG C. Catalytic agents such as dimethylaminopyridine and triethylamine may also be added to accelerate the reaction. Protected intermediates of the anhydronucleosides and aminooxazolines are also disclosed.
Inventors:
Charles William Marty Asio
Application Number:
JP17787689A
Publication Date:
January 25, 1995
Filing Date:
July 10, 1989
Export Citation:
Assignee:
Father Incorporated
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7072; A61P31/12; A61P31/18; C07H9/06; C07H19/06; (IPC1-7): C07H19/06
Domestic Patent References:
| JP5649398A |
Other References:
【文献】米国特許4140850(US,A)
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)
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