Title:
【発明の名称】尿素誘導体とACAT阻害剤としての用途
Document Type and Number:
Japanese Patent JPH10510512
Kind Code:
A
Abstract:
Urea derivatives of formula (I), wherein R<1> is a group of formula (1) (in which R<4> is aryl which may have suitable substituent(s), or heterocyclic group which may have suitable substituent(s), and Y is bond, lower alkylene, -S-, -O-, (a), =CH-, -CONH-, (b), (in which R<7> is lower alkyl), -NHSO2-, -SO2NH-, -SO2NHCO- or -CONHSO2-); or thiazolyl, imidazolyl, pyrazolyl, pyridyl, thienyl, furyl, isoxazolyl or chromanyl, each of which may have suitable substituent(s); R<2> is lower alkyl, lower alkoxy(lower)alkyl, cycloalkyl, ar(lower)alkyl which may have suitable substituent(s), heterocyclic group or heterocyclic(lower)alkyl, R<3> is aryl which may have suitable substituent(s) or heterocyclic group which may have suitable substituent(s), and n is 0 or 1, and a pharmaceutically acceptable salt thereof which are useful as a medicament in the treatment of hypercholesterolemia, hyperlipidemia and atherosclerosis.
Inventors:
Takeshi Terasawa
Akira Tanaka
Toshiyuki Chiba
Hisashi Takasugi
Akira Tanaka
Toshiyuki Chiba
Hisashi Takasugi
Application Number:
JP51161696A
Publication Date:
October 13, 1998
Filing Date:
September 29, 1995
Export Citation:
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
International Classes:
A61K31/17; A61K31/18; A61K31/34; A61K31/35; A61K31/352; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/395; A61K31/40; A61K31/415; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/44; A61K31/4427; A61K31/443; A61K31/445; A61K31/495; A61K31/496; A61K31/505; A61K31/54; A61P3/06; A61P9/10; C07C275/26; C07C275/28; C07C275/30; C07C275/32; C07C275/38; C07C275/40; C07C275/42; C07C311/08; C07C311/21; C07C311/47; C07C311/51; C07C323/44; C07D207/325; C07D211/14; C07D213/40; C07D295/12; C07D213/70; C07D213/74; C07D213/75; C07D213/81; C07D231/12; C07D233/54; C07D233/61; C07D239/58; C07D249/08; C07D257/04; C07D261/08; C07D263/32; C07D271/10; C07D277/20; C07D277/28; C07D277/34; C07D295/135; C07D307/52; C07D311/58; C07D311/72; C07D317/58; C07D333/16; C07D333/20; C07D401/12; C07D403/12; C07D405/12; C07D417/12; C07D521/00; C07D207/32; (IPC1-7): C07C275/28; C07D417/12; C07D405/12; C07D403/12; C07D401/12; C07D333/16; C07D317/58; C07D311/58; C07D295/12; C07D277/34; C07D263/32; C07D261/08; C07D257/04; C07D233/61; C07D231/12; C07D213/81; C07D213/74; C07D213/70; C07D213/40; C07D211/14; C07D207/325; C07C323/44; C07C311/51; C07C311/21; C07C311/08; C07C275/26; A61K31/54; A61K31/505; A61K31/495; A61K31/445; A61K31/44; A61K31/425; A61K31/42; A61K31/415; A61K31/40; A61K31/395; A61K31/38; A61K31/36; A61K31/35; A61K31/34; A61K31/18; A61K31/17