Title:
ＨＳＰ４７発現の調節を増強するレチノイド−リポソーム
Document Type and Number:
Japanese Patent JP2014519516
Kind Code:
A
Abstract:
What is described are pharmaceutical compositions comprising a double-stranded nuclei acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNH1-45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.
Inventors:
Niitsu 洋司郎
A pane, Joseph E.
キノポヴ, Victor
アコピアン, ヴィオレッタ
Witte, Richard Py.
Erma Diana, Mohammad
ペレルマン, Lorain Ey.
Tanaka 康進
Fine Stein, Elena
アヴキン * ナフム, Sharon
Carlinsky, ハガール
A helmet, Igor
Kenjiro Minomi
An inn, WIN Bin
リウ, Yoon
A pane, Joseph E.
キノポヴ, Victor
アコピアン, ヴィオレッタ
Witte, Richard Py.
Erma Diana, Mohammad
ペレルマン, Lorain Ey.
Tanaka 康進
Fine Stein, Elena
アヴキン * ナフム, Sharon
Carlinsky, ハガール
A helmet, Igor
Kenjiro Minomi
An inn, WIN Bin
リウ, Yoon
Application Number:
JP2014514911A
Publication Date:
August 14, 2014
Filing Date:
June 08, 2012
Export Citation:
Assignee:
NITTO DENKO CORP.
International Classes:
A61K48/00; A61K9/107; A61K9/127; A61K31/07; A61K31/203; A61K31/713; A61K47/48; A61P1/02; A61P1/16; A61P1/18; A61P31/14; A61P43/00; C12N15/09
Domestic Patent References:
| JP2010539245A | 2010-12-16 | |||
| JP2013514761A | 2013-05-02 |
Attorney, Agent or Firm:
Mitsuhashi 規樹
Seiji Kuzuwa
Seiji Kuzuwa