1, 2-DI(CYCLIC GROUP)SUBSTITUTED BENZENE DERIVATIVE

Title:

1, 2-DI(CYCLIC GROUP)SUBSTITUTED BENZENE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2006/134955

Kind Code:

A1

Abstract:

A compound represented by the general formula (1) or (100), a salt thereof or a hydrate of the compound or salt, which is excellent in cell adhesion-inhibitory effect and cell infiltration-inhibitory effect: (1) (100) wherein R¹⁰ represents a 5- to 10-membered cycloalkyl group which may be substituted by a hydroxyl group or the like, etc.; R³⁰, R³¹ and R³² independently represent a hydrogen atom, etc.; R⁴⁰ represents a C1-10 alkyl group which may be substituted by a hydroxyl group or the like, etc.; n represents an integer of 0, 1 or 2; X¹ represents a group represented by the formula: CH or a nitrogen atom; R²⁰, R²¹, R²² and R²³ independently represent a hydrogen atom, etc.

Inventors:

KAWAHARA TETSUYA (JP)
KOTAKE MAKOTO (JP)
YONEDA NAOKI (JP)
HIROTA SHINSUKE (JP)
OHKURO MASAYOSHI (JP)

Application Number:

PCT/JP2006/311900

Publication Date:

December 21, 2006

Filing Date:

June 14, 2006

Export Citation:

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Assignee:

EISAI R&D MAN CO LTD (JP)
KAWAHARA TETSUYA (JP)
KOTAKE MAKOTO (JP)
YONEDA NAOKI (JP)
HIROTA SHINSUKE (JP)
OHKURO MASAYOSHI (JP)

International Classes:

C07D207/08; A61K31/495; A61K31/496; A61K31/5377; A61K31/538; A61K31/54; A61P1/04; A61P11/06; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C07D207/27; C07D207/404; C07D211/22; C07D211/46; C07D211/58; C07D211/62; C07D211/74; C07D211/76; C07D211/88; C07D213/64; C07D263/56; C07D265/36; C07D277/64; C07D279/12; C07D295/02; C07D295/08; C07D295/10; C07D295/12; C07D295/14; C07D295/18; C07D295/20; C07D309/14; C07D317/66; C07D319/18; C07D407/12; C07D413/12; C07D491/113

Domestic Patent References:

WO2005063705A1

2005-07-14

Foreign References:

JP2004523529A	2004-08-05
JPH05186434A	1993-07-27
JP2003506377A	2003-02-18
JP2005505621A	2005-02-24

Other References: