Title:
1'-SUBSTITUTED PYRIMIDINE N-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
Document Type and Number:
WIPO Patent Application WO/2012/142523
Kind Code:
A3
Abstract:
Provided are compounds of Formula I: nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2- haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.
Inventors:
CHO AESOP (US)
KIM CHOUNG U (US)
KIRSCHBERG THORSTEN A (US)
MISH MICHAEL R (US)
SQUIRES NEIL (US)
KIM CHOUNG U (US)
KIRSCHBERG THORSTEN A (US)
MISH MICHAEL R (US)
SQUIRES NEIL (US)
Application Number:
PCT/US2012/033675
Publication Date:
June 27, 2013
Filing Date:
April 13, 2012
Export Citation:
Assignee:
GILEAD SCIENCES INC (US)
CHO AESOP (US)
KIM CHOUNG U (US)
KIRSCHBERG THORSTEN A (US)
MISH MICHAEL R (US)
SQUIRES NEIL (US)
CHO AESOP (US)
KIM CHOUNG U (US)
KIRSCHBERG THORSTEN A (US)
MISH MICHAEL R (US)
SQUIRES NEIL (US)
International Classes:
C07H19/06; C07H19/067; C07H19/073; C07H19/09; C07H19/10; C07H19/11
Domestic Patent References:
| WO2001090121A2 | 2001-11-29 |
Other References:
HAIDONG HUANG ET AL: "Competitive Inhibition of Uracil DNA Glycosylase by a Modified Nucleotide Whose Triphosphate is a Substrate for DNA Polymerase", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, no. 4, 4 February 2009 (2009-02-04), pages 1344 - 1345, XP055054894, ISSN: 0002-7863, DOI: 10.1021/ja807705z
PETER GRÜNEFELD ET AL: "Synthesis of a 1'-Aminomethylthymidine and Oligodeoxyribonucleotides with 1'-Acylamidomethylthymidine Residues", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 69, no. 22, 1 October 2004 (2004-10-01), pages 7543 - 7551, XP055054901, ISSN: 0022-3263, DOI: 10.1021/jo049062o
TETSUYA KODAMA ET AL: "Nucleosides and nucleotides. Part 205. An efficient method for the preparation of 1'.alpha.-branched-chain sugar pyrimidine ribonucleosides from uridine: the first conversion of a natural nucleoside into 1'-substituted ribonucleosides", CHEMISTRY - A EUROPEAN JOURNAL, vol. 7, no. 11, 1 June 2001 (2001-06-01), pages 2332 - 2340, XP055054907, ISSN: 0947-6539, DOI: 10.1002/1521-3765(20010601)7:11<2332::AID-CHEM23320>3.0.CO;2-W 2332
VALÉRIE UTEZA ET AL: "Synthesis and structure determination of the first 1'-C-cyano-[beta]-D-nucleosides", TETRAHEDRON, vol. 49, no. 38, 1 September 1993 (1993-09-01), pages 8579 - 8588, XP055054911, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)96264-7
PETER GRÜNEFELD ET AL: "Synthesis of a 1'-Aminomethylthymidine and Oligodeoxyribonucleotides with 1'-Acylamidomethylthymidine Residues", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 69, no. 22, 1 October 2004 (2004-10-01), pages 7543 - 7551, XP055054901, ISSN: 0022-3263, DOI: 10.1021/jo049062o
TETSUYA KODAMA ET AL: "Nucleosides and nucleotides. Part 205. An efficient method for the preparation of 1'.alpha.-branched-chain sugar pyrimidine ribonucleosides from uridine: the first conversion of a natural nucleoside into 1'-substituted ribonucleosides", CHEMISTRY - A EUROPEAN JOURNAL, vol. 7, no. 11, 1 June 2001 (2001-06-01), pages 2332 - 2340, XP055054907, ISSN: 0947-6539, DOI: 10.1002/1521-3765(20010601)7:11<2332::AID-CHEM23320>3.0.CO;2-W 2332
VALÉRIE UTEZA ET AL: "Synthesis and structure determination of the first 1'-C-cyano-[beta]-D-nucleosides", TETRAHEDRON, vol. 49, no. 38, 1 September 1993 (1993-09-01), pages 8579 - 8588, XP055054911, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)96264-7
Attorney, Agent or Firm:
RUSSO, Alicia A. et al. (Cella Harper & Scinto,1290 Avenue of The America, New York NY, US)
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