1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-

Title:

1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-

Document Type and Number:

WIPO Patent Application WO2002055516

Kind Code:

A3

Abstract:

The present application describes novel 1,1-disubstituted cyclic derivatives of formula (I), or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-8 membered non-aromatic ring consisting of: carbon atoms, 0-1 carbonyl groups, 0-1 double bonds, and from 0-2 ring heteroatoms selected from O, N, NR2, S, S(O), and S(O)2 and the other variables are defined in the present specification, which are useful as metalloprotease and as TNF- inhibitors.

Inventors:

CHEN XIAO-TAO
XUE CHU-BIAO

Application Number:

PCT/US2002/000761

Publication Date:

August 29, 2002

Filing Date:

January 09, 2002

Export Citation:

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Assignee:

BRISTOL MYERS SQUIBB CO (US)

International Classes:

C07D215/14; C07D401/12; C07D401/14; C07D405/12; C07D413/12; (IPC1-7): C07D401/12

Foreign References:

US5179105A

1993-01-12

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