Title:
1,3,4-OXADIAZOLE-2-CYCLOBUTYL COMPOUNDS, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/083336
Kind Code:
A1
Abstract:
The present invention relates to the field of medicinal chemistry, and relates to a class of 1,3,4-oxadiazole-2-cyclobutyl compounds or a pharmaceutically acceptable salt, hydrate, solvate or crystal thereof, and a preparation method therefor and an application thereof. Specifically, provided by the present invention are (((1r,3S)-1-(5-((1S,2R)-1-amino-2-hydroxypropyl)-1,3,4-oxadiazole-2-yl)-3-(cyanomethyl) cyclobutyl) carbamoyl)-L-serine represented by formula (I) or a pharmaceutically acceptable salt, hydrate, solvate or crystal thereof, a method for preparing same, and an application in the treatment of cancer or infectious diseases, (I).
Inventors:
WANG YONG (CN)
ZHAO LIWEN (CN)
LIU XIN (CN)
LI YANG (CN)
ZHANG JIN (CN)
CHEN CHENG (CN)
ZHAO LIWEN (CN)
LIU XIN (CN)
LI YANG (CN)
ZHANG JIN (CN)
CHEN CHENG (CN)
Application Number:
PCT/CN2019/113000
Publication Date:
April 30, 2020
Filing Date:
October 24, 2019
Export Citation:
Assignee:
NANJING SANHOME PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4245; C07D271/10; A61P31/00; A61P35/00
Domestic Patent References:
| WO2015033301A1 | 2015-03-12 | |||
| WO2018196768A1 | 2018-11-01 |
Foreign References:
| CN107405336A | 2017-11-28 |
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
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