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Title:
1,3,5-TRIAZINE DERIVATIVE SALT, CRYSTAL, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/133856
Kind Code:
A1
Abstract:
The invention discloses a crystal of 4-(tert-butoxyamino)-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine compound, a mesylate salt and crystal thereof, a preparation method thereof, a composition containing thereof, and a use thereof for inhibiting activity of mutant IDH2 and treating cancer.

Inventors:
HUANG TICONG (CN)
XIAO HUIFENG (CN)
ZHAO RUI (CN)
LIU FEI (CN)
WEI WEI (CN)
XU HONGJIANG (CN)
WANG XIAOJIN (CN)
WU JINGLI (CN)
Application Number:
PCT/CN2018/073578
Publication Date:
July 26, 2018
Filing Date:
January 22, 2018
Export Citation:
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Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO LTD (CN)
CENTAURUS BIOPHARMA CO LTD (CN)
International Classes:
C07D401/14; A61K31/5377; A61P35/00
Domestic Patent References:
WO2017016513A12017-02-02
Foreign References:
CN104114543A2014-10-22
CN107641114A2018-01-30
Other References:
See also references of EP 3572409A4
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT, WILLIAMS & WILKINS
"Chinese Pharmacopoeia", 2010, article "Guiding Principles for Drug Hygroscopicity Test"
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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