Title:
1,4-DIAZOCANE COMPOUND OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/091054
Kind Code:
A1
Abstract:
The invention provides a novel production method for an isoquinoline-6-sulfonamide derivative that is useful as a medicinal drug, and also provides an intermediate for use in the method.
The invention is the 1,4-diazocane compound represented by general formula (A), or a salt thereof (in the formula, R4 represents an amino-protecting group).
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Inventors:
SUMI KENGO (JP)
KOIDE TOMOYUKI (JP)
KIMATA OSAMU (JP)
TAKASHIMA YUJI (JP)
MASUBUCHI KAZUNAO (JP)
KOIDE TOMOYUKI (JP)
KIMATA OSAMU (JP)
TAKASHIMA YUJI (JP)
MASUBUCHI KAZUNAO (JP)
Application Number:
PCT/JP2019/043068
Publication Date:
May 07, 2020
Filing Date:
November 01, 2019
Export Citation:
Assignee:
D WESTERN THERAPEUTICS INST INC (JP)
WAKAMOTO PHARMA CO LTD (JP)
WAKAMOTO PHARMA CO LTD (JP)
International Classes:
C07C311/18; C07D245/02; C07D401/12
Foreign References:
| US20080064681A1 | 2008-03-13 | |||
| JPS4915010B1 | 1974-04-11 | |||
| JPS4915010B1 | 1974-04-11 |
Other References:
DATABASE RN 7 December 2015 (2015-12-07), retrieved from STN Database accession no. 1824139-45-8
DATABASE RN 15 June 2016 (2016-06-15), retrieved from STN Database accession no. 1932491-82-1
DATABASE RN 15 June 2016 (2016-06-15), retrieved from STN Database accession no. 1932077-61-6
DATABASE RN 24 April 2016 (2016-04-24), retrieved from STN Database accession no. 1896106-17-1
DATABASE RN 15 April 2016 (2016-04-15), retrieved from STN Database accession no. 1890622-72-6
DATABASE RN 18 April 2016 (2016-04-18), retrieved from STN Database accession no. 1892420-96-0
DATABASE RN 7 December 2015 (2015-12-07), retrieved from STN Database accession no. 1824339-52-7
DATABASE RN 7 March 2014 (2014-03-07), retrieved from STN Database accession no. 1563605-04-8
THEODORA W. GREENE; PETER G. M. WUTS: "Protection for the Amino Group", PROTECTIVE GROUPS IN ORGANIC SYNTHESIS, vol. 3rd ed., 1999, pages 494 - 653, XP009527465, ISBN: 0-471-16019-9, DOI: 10.1002/0471220574.ch7
SUMI, K. ET AL.: "IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, no. 3, 2014, pages 831 - 834, XP028819897, DOI: 10.1016/j.bmcl.2013.12.085
JIE JACK LI: "Mitsunobu reaction", NAME REACTIONS - A COLLECTION OF DETAILED REACTION MECHANISMS, vol. 2nd ed., 2003, pages 265, XP009527466, ISBN: 3-540-40203-9, DOI: 10.1007/978-3-662-05336-2_198
DATABASE RN 15 June 2016 (2016-06-15), retrieved from STN Database accession no. 1932491-82-1
DATABASE RN 15 June 2016 (2016-06-15), retrieved from STN Database accession no. 1932077-61-6
DATABASE RN 24 April 2016 (2016-04-24), retrieved from STN Database accession no. 1896106-17-1
DATABASE RN 15 April 2016 (2016-04-15), retrieved from STN Database accession no. 1890622-72-6
DATABASE RN 18 April 2016 (2016-04-18), retrieved from STN Database accession no. 1892420-96-0
DATABASE RN 7 December 2015 (2015-12-07), retrieved from STN Database accession no. 1824339-52-7
DATABASE RN 7 March 2014 (2014-03-07), retrieved from STN Database accession no. 1563605-04-8
THEODORA W. GREENE; PETER G. M. WUTS: "Protection for the Amino Group", PROTECTIVE GROUPS IN ORGANIC SYNTHESIS, vol. 3rd ed., 1999, pages 494 - 653, XP009527465, ISBN: 0-471-16019-9, DOI: 10.1002/0471220574.ch7
SUMI, K. ET AL.: "IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, no. 3, 2014, pages 831 - 834, XP028819897, DOI: 10.1016/j.bmcl.2013.12.085
JIE JACK LI: "Mitsunobu reaction", NAME REACTIONS - A COLLECTION OF DETAILED REACTION MECHANISMS, vol. 2nd ed., 2003, pages 265, XP009527466, ISBN: 3-540-40203-9, DOI: 10.1007/978-3-662-05336-2_198
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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