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Title:
2-ALKYNYL MANNOSE DERIVATIVE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/197363
Kind Code:
A1
Abstract:
The present invention relates to a 2-alkynyl mannose derivative and an application thereof. The mannose derivative, as well as a pharmaceutically acceptable salt, an isotope and an isomer thereof have the structure represented by general formula I. The derivative is used for the treatment or prevention of bacterial infections. Further provided by the present invention is a pharmaceutically acceptable composition comprising the compound and an application thereof in the treatment or prevention of the bacterial infections.

Inventors:
ZHENG JIYUE (CN)
WANG XIAOLEI (CN)
Application Number:
PCT/CN2021/084235
Publication Date:
October 07, 2021
Filing Date:
March 31, 2021
Export Citation:
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Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07H7/02; A61K31/7034; A61P13/00; A61P31/04; C07H15/203
Domestic Patent References:
WO2020012336A12020-01-16
Foreign References:
CN107849031A2018-03-27
CN105682665A2016-06-15
CN108883122A2018-11-23
CN108778288A2018-11-09
CN102753562A2012-10-24
Other References:
ZHENFU HAN; JEROME S PINKNER; BRADLEY FORD; ERIK CHORELL; JAN M CROWLEY; CORINNE K CUSUMANO; SCOTT CAMPBELL; JEFFREY P HENDERSON; : "Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 8, 26 April 2012 (2012-04-26), pages 3945 - 3959, XP055065272, ISSN: 1520-4804, DOI: 10.1021/jm300165m
ZHENFU HAN; JEROME S PINKNER; BRADLEY FORD; ROBERT OBERMANN; WILLIAM NOLAN; SCOTT A WILDMAN; DOUG HOBBS; TOM ELLENBERGER; CORINNE : "Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 12, 24 June 2010 (2010-06-24), pages 4779 - 4792, XP002620405, ISSN: 1520-4804, DOI: 10.1021/jm100438s
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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