Title:
2'-FLUORO-6'-METHYLENE CARBOCYCLIC NUCEOSIDES AND METHODS OF TREATING VIRAL INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2012/158552
Kind Code:
A3
Abstract:
The present invention relates to 2'-Fluoro-6'-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.
Inventors:
CHU CHUNG K (US)
WANG JIANING (US)
WANG JIANING (US)
Application Number:
PCT/US2012/037612
Publication Date:
January 24, 2013
Filing Date:
May 11, 2012
Export Citation:
Assignee:
UNIV GEORGIA (US)
CHU CHUNG K (US)
WANG JIANING (US)
CHU CHUNG K (US)
WANG JIANING (US)
International Classes:
C07H19/04; A61K31/7052; A61P31/12; C07H19/06; C07H19/10; C07H19/16; C07H19/20
Foreign References:
| US20040110718A1 | 2004-06-10 | |||
| US20020198171A1 | 2002-12-26 | |||
| US20040157793A1 | 2004-08-12 | |||
| US20070042940A1 | 2007-02-22 | |||
| US5340816A | 1994-08-23 | |||
| US20070225249A1 | 2007-09-27 |
Other References:
WANG, J. ET AL.: "Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants .", BIOORG. & MED. CHEM. LETT., vol. 21, 1 September 2011 (2011-09-01), pages 6328 - 6331
WANG, J. ET AL.: "D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.", J. MED. CHEM., vol. 50, no. 8, 19 April 2007 (2007-04-19), pages 1828 - 1839
WANG, J. ET AL.: "D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.", J. MED. CHEM., vol. 50, no. 8, 19 April 2007 (2007-04-19), pages 1828 - 1839
Attorney, Agent or Firm:
COLEMAN, Henry, D. (P.C.714 Colorado Avenu, Bridgesport CT, US)
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