Title:
2,3-DIHYDRO-1H-INDENE-2-YLUREA DERIVATIVE AND PHARMACEUTICAL APPLICATION OF SAME
Document Type and Number:
WIPO Patent Application WO/2011/040509
Kind Code:
A1
Abstract:
In order to provide a low molecular weight compound that has p38MAPK inhibitory activity and the accompanying TNFα production suppression activity and that has a favorable pharmacokinetic profile as a pharmaceutical and decreased hepatotoxicity, and to provide a pharmaceutical application of same, disclosed is a 2,3-dihydro-1H-indene-2-ylurea derivative represented below, a pharmacologically acceptable salt thereof, and a therapeutic agent or preventative agent that contains same as an active ingredient and that is for allergic dermatitis, inflammatory bowel disease, and pain.
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Inventors:
KANEKO HIROAKI (JP)
KAWAI HIDEKI (JP)
IURA YOSUKE (JP)
INOUE HIDEKI (JP)
KAINO MIE (JP)
MEGURO HIROYUKI (JP)
UCHIDA TAZURU (JP)
KAWAI HIDEKI (JP)
IURA YOSUKE (JP)
INOUE HIDEKI (JP)
KAINO MIE (JP)
MEGURO HIROYUKI (JP)
UCHIDA TAZURU (JP)
Application Number:
PCT/JP2010/067047
Publication Date:
April 07, 2011
Filing Date:
September 30, 2010
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
KANEKO HIROAKI (JP)
KAWAI HIDEKI (JP)
IURA YOSUKE (JP)
INOUE HIDEKI (JP)
KAINO MIE (JP)
MEGURO HIROYUKI (JP)
UCHIDA TAZURU (JP)
KANEKO HIROAKI (JP)
KAWAI HIDEKI (JP)
IURA YOSUKE (JP)
INOUE HIDEKI (JP)
KAINO MIE (JP)
MEGURO HIROYUKI (JP)
UCHIDA TAZURU (JP)
International Classes:
C07C275/34; A61K31/17; A61K31/35; A61P17/00; A61P29/00; C07C275/40; C07D295/12; C07D309/06
Domestic Patent References:
WO1999000357A1 | 1999-01-07 | |||
WO2002083642A1 | 2002-10-24 | |||
WO2007103468A2 | 2007-09-13 | |||
WO2000043384A1 | 2000-07-27 | |||
WO1993014081A1 | 1993-07-22 | |||
WO2007073503A2 | 2007-06-28 | |||
WO2004082687A1 | 2004-09-30 |
Foreign References:
JPH03261755A | 1991-11-21 | |||
JP2005500400A | 2005-01-06 | |||
JP2001526276A | 2001-12-18 | |||
JP2007145819A | 2007-06-14 | |||
JP2006528986A | 2006-12-28 | |||
JP2005508357A | 2005-03-31 | |||
JP2003512378A | 2003-04-02 | |||
JP2002517486A | 2002-06-18 | |||
JPH03261755A | 1991-11-21 |
Other References:
KOJ, BIOCHIM. BIOPHYS. ACTA, vol. 1317, 1996, pages 84 - 94
DINARELLO ET AL., REV. INFECT. DISEASE, vol. 6, 1984, pages 51 - 95
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 15, 2008, pages 7193 - 7205
SYNTHESIS, vol. 7, 1998, pages 1029 - 1032
TETRAHEDRON LETTERS, vol. 34, no. 52, 1993, pages 8399 - 8402
YAKUGAKUZASSHI, vol. 99, no. 11, 1979, pages 1111 - 1115
TETRAHEDRON: ASYMMETRY, vol. 6, no. 7, 1995, pages 1535 - 1538
INFLAMM. RES., vol. 47, 1998, pages 506 - 511
INT. ARCH. ALLERGY. APPL. IMMUNOL., vol. 92, 1990, pages 356 - 360
GASTROENTEROLOGY, vol. 96, 1989, pages 29 - 36
AM. J. PHYSIOL. GASTROINTEST. LIVER PHYSIOL., vol. 287, 2004, pages 15 - 124
GASTROENTEROLOGY, vol. 37, 2002, pages 409 - 417
ANESTH. ANALG., vol. 108, 2009, pages 1680 - 1687
PAIN, vol. 33, 1988, pages 87 - 107
PAIN, vol. 50, 1992, pages 355 - 363
CURRENT MEDICINAL CHEMISTRY, 2004, pages 721 - 730
JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, 2003, pages 4676 - 4686
JOURNAL OF IMMUNOLOGY, vol. 148, 1992, pages 1890 - 1897
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol. 58, 2007, pages 375 - 382
CELL BIOLOGY AND TOXICOLOGY, vol. 19, 2003, pages 161 - 176
AM. J. PHYSIOL. GASTROINTEST. LIVER PHYSIOL., vol. 287, 2004, pages 15 - 124
DUBIGEON ET AL., EUR. J PHARMACOL., vol. 431, 2001, pages 103 - 110
VENKOVA ET AL., J PHARMACOL. EXP. THER., vol. 308, 2004, pages 206 - 213
See also references of EP 2484661A4
DINARELLO ET AL., REV. INFECT. DISEASE, vol. 6, 1984, pages 51 - 95
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, no. 15, 2008, pages 7193 - 7205
SYNTHESIS, vol. 7, 1998, pages 1029 - 1032
TETRAHEDRON LETTERS, vol. 34, no. 52, 1993, pages 8399 - 8402
YAKUGAKUZASSHI, vol. 99, no. 11, 1979, pages 1111 - 1115
TETRAHEDRON: ASYMMETRY, vol. 6, no. 7, 1995, pages 1535 - 1538
INFLAMM. RES., vol. 47, 1998, pages 506 - 511
INT. ARCH. ALLERGY. APPL. IMMUNOL., vol. 92, 1990, pages 356 - 360
GASTROENTEROLOGY, vol. 96, 1989, pages 29 - 36
AM. J. PHYSIOL. GASTROINTEST. LIVER PHYSIOL., vol. 287, 2004, pages 15 - 124
GASTROENTEROLOGY, vol. 37, 2002, pages 409 - 417
ANESTH. ANALG., vol. 108, 2009, pages 1680 - 1687
PAIN, vol. 33, 1988, pages 87 - 107
PAIN, vol. 50, 1992, pages 355 - 363
CURRENT MEDICINAL CHEMISTRY, 2004, pages 721 - 730
JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, 2003, pages 4676 - 4686
JOURNAL OF IMMUNOLOGY, vol. 148, 1992, pages 1890 - 1897
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol. 58, 2007, pages 375 - 382
CELL BIOLOGY AND TOXICOLOGY, vol. 19, 2003, pages 161 - 176
AM. J. PHYSIOL. GASTROINTEST. LIVER PHYSIOL., vol. 287, 2004, pages 15 - 124
DUBIGEON ET AL., EUR. J PHARMACOL., vol. 431, 2001, pages 103 - 110
VENKOVA ET AL., J PHARMACOL. EXP. THER., vol. 308, 2004, pages 206 - 213
See also references of EP 2484661A4
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