Title:
23-YNE-VITAMIN D3 DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2012/057068
Kind Code:
A1
Abstract:
Provided is a novel vitamin D3 derivative which is useful as a therapeutic agent for osteoporosis.
Specifically provided is a vitamin D3 derivative represented by formula (1) or a pharmaceutically acceptable solvate thereof.
In the formula, R1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, an alkylcarbonyloxyalkyl group (wherein each alkyl has 1-6 carbon atoms) or an arylcarbonyloxyalkyl group (wherein the aryl has 6-10 carbon atoms and the alkyl has 1-6 carbon atoms); R2 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms, or alternatively R2 may form, together with the other R2 and carbon atoms bonded to the R2 moieties, a cyclic alkyl group having 3-6 carbon atoms; R3 represents an alkyl group having 1-6 carbon atoms, or alternatively R3 may form, together with the other R3 and carbon atoms bonded to the R3 moieties, a cyclic alkyl group having 3-6 carbon atoms; X represents an oxygen atom or a methylene group; and n represents an integer of 1 or 2.
Inventors:
SAITO HIROSHI (JP)
KOMIYAMA MASATO (JP)
OCHIAI EIJI (JP)
TAKAGI KENICHIRO (JP)
CHIDA TAKAYUKI (JP)
FUJITA MARIKO (JP)
IMAIZUMI KEIICHIRO (JP)
KANEKO TOSHIYUKI (JP)
KOMIYAMA MASATO (JP)
OCHIAI EIJI (JP)
TAKAGI KENICHIRO (JP)
CHIDA TAKAYUKI (JP)
FUJITA MARIKO (JP)
IMAIZUMI KEIICHIRO (JP)
KANEKO TOSHIYUKI (JP)
Application Number:
PCT/JP2011/074414
Publication Date:
May 03, 2012
Filing Date:
October 24, 2011
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
SAITO HIROSHI (JP)
KOMIYAMA MASATO (JP)
OCHIAI EIJI (JP)
TAKAGI KENICHIRO (JP)
CHIDA TAKAYUKI (JP)
FUJITA MARIKO (JP)
IMAIZUMI KEIICHIRO (JP)
KANEKO TOSHIYUKI (JP)
SAITO HIROSHI (JP)
KOMIYAMA MASATO (JP)
OCHIAI EIJI (JP)
TAKAGI KENICHIRO (JP)
CHIDA TAKAYUKI (JP)
FUJITA MARIKO (JP)
IMAIZUMI KEIICHIRO (JP)
KANEKO TOSHIYUKI (JP)
International Classes:
A61K31/593; C07C401/00; A61P19/10; C07F7/18
Domestic Patent References:
| WO1999052863A1 | 1999-10-21 | |||
| WO1999003829A1 | 1999-01-28 | |||
| WO2001062723A1 | 2001-08-30 | |||
| WO2001062723A1 | 2001-08-30 | |||
| WO1998058909A1 | 1998-12-30 |
Foreign References:
| JP2009256361A | 2009-11-05 | |||
| JP2009013154A | 2009-01-22 | |||
| US4804502A | 1989-02-14 |
Other References:
TAKAYAMA ET AL.: "Recent Results in Cancer Research", vol. 164, 2003, SPRINGER, article "Vitamin D Analog in Cancer Prevention and Therapy", pages: 289 - 317
KITTAKA ET AL., J. ORG. CHEM., vol. 69, 2004, pages 7463 - 7471
SAITO ET AL., TETRAHEDRON, vol. 60, 2004, pages 7951 - 7961
OZONO ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, 1990, pages 21881 - 21888
See also references of EP 2634171A4
KITTAKA ET AL., J. ORG. CHEM., vol. 69, 2004, pages 7463 - 7471
SAITO ET AL., TETRAHEDRON, vol. 60, 2004, pages 7951 - 7961
OZONO ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, 1990, pages 21881 - 21888
See also references of EP 2634171A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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Claims: