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Title:
3'-OR 2'-HYDROXYMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES FOR TREATMENT OF HEPATITIS VIRUS INFECTIONS
Document Type and Number:
WIPO Patent Application WO2001079246
Kind Code:
A3
Abstract:
The present invention relates to a composition for and a method of treating hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, hepatitis D virus (HDV) infection or a proliferative disorder in a patient using an effective amount of a compound selected from the group consisting of formulas (I)-(IV) below and mixtures of two or more thereof, wherein the substituents are as defined herein. Pharmaceutical compositions comprising these compounds in combination with other HBV, HCV, or HDV agents is also disclosed.

Inventors:
WATANABE KYOICHI A (US)
PAI BALAKRISHNA S (US)
Application Number:
PCT/US2001/012050
Publication Date:
August 15, 2002
Filing Date:
April 13, 2001
Export Citation:
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Assignee:
PHARMASSET LTD (BB)
WATANABE KYOICHI A (US)
PAI BALAKRISHNA S (US)
International Classes:
A61K31/13; A61K31/513; A61K31/52; A61K31/5383; A61K31/662; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/712; A61K38/00; A61K38/21; A61P1/16; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; C07D405/04; C07D413/04; C07D493/04; C07H19/06; C07H19/10; C07H19/16; C07H19/20; (IPC1-7): A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61P31/12; A61P35/00
Foreign References:
US6004939A1999-12-21
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TSIBINOGIN, V. V. ET AL: "Inhibition of the replication of human hepatitis B virus", XP002192805, retrieved from STN Database accession no. 111:126519
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MATTHES, ECKART ET AL: "Comparative inhibition of hepatitis B virus DNA polymerase and cellular DNA polymerases by triphosphates of sugar-modified 5-methyldeoxycytidines and of other nucleoside analogs", XP002192806, retrieved from STN Database accession no. 115:154849
VICTOROVA LYUBOV S ET AL: "Mode of inhibition of HIV reverse transcriptase-catalyzed DNA synthesis by 3'-amino-3'-deoxythymidine 5'-triphosphate.", NUCLEOSIDES & NUCLEOTIDES, vol. 15, no. 1-3, 1996, pages 655 - 667, XP001062295, ISSN: 0732-8311
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; UEDA, TORU ET AL: "Preparation of 2'-deoxy-2'(S)-alkylpyrimidine nucleosides as antiviral agents", XP002192807, retrieved from STN Database accession no. 110:115271 CA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MATSUDA, AKIRA ET AL: "Preparation of 2'-deoxy-(2'S)-alkylpyrimidine nucleosides as antiviral agents", XP002192808, retrieved from STN Database accession no. 122:31836 CA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MATTHES, E. ET AL: "Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides", XP002192809, retrieved from STN Database accession no. 114:17138 HCA
MCGUIGAN C ET AL: "Alkyl Hydrogen Phosphonate Derivatives of the Anti-HIV Agent AZT may be Less Toxic than the Parent Nucleoside Analogue", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, BLACKWELL SCIENTIFIC PUBL., LONDON, GB, vol. 5, no. 4, 1994, pages 271 - 277, XP002105798, ISSN: 0956-3202
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