3-ARYLOXYL-3-FIVE-MEMBERED HETEROARYL PROPYLAMINE COMPOUND, AND CRYSTAL FORM AND USE THEREOF

Title:

3-ARYLOXYL-3-FIVE-MEMBERED HETEROARYL PROPYLAMINE COMPOUND, AND CRYSTAL FORM AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2020/228789

Kind Code:

A1

Abstract:

The present invention relates to a 3-aryloxyl-3-five-membered heteroaryl propylamine compound, and crystal form and use thereof. Specifically, the present invention provides a compound, or a pharmaceutically acceptable salt or a prodrug thereof, the compound having a structure of formula I. The compound, or pharmaceutically acceptable salt or prodrug thereof of the present invention has an excellent inhibition function for a transient receptor potential channel protein (TPR), and has a good treatment function for diseases associated with the TPR.

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Inventors:

WANG YOUXIN (CN)
ZHANG LINGLING (CN)
DING QIANG (CN)

Application Number:

PCT/CN2020/090354

Publication Date:

November 19, 2020

Filing Date:

May 14, 2020

Export Citation:

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Assignee:

SHANGHAI LEADO PHARMATECH CO LTD (CN)

International Classes:

C07D409/12; A61K31/381; A61K31/397; A61K31/4025; A61K31/4525; A61K31/496; A61K31/5377; A61P1/00; A61P1/04; A61P11/00; A61P11/06; A61P13/02; A61P17/04; A61P29/00; C07D343/00; C07D407/12

Domestic Patent References:

WO2020035040A1	2020-02-20
WO2020035070A1	2020-02-20
WO2018115064A1	2018-06-28
WO2002094262A1	2002-11-28
WO2011060962A1	2011-05-26
WO2010075353A1	2010-07-01

Foreign References:

CN107840845A	2018-03-27
CN105497019A	2016-04-20
CN107625762A	2018-01-26
CN101657438A	2010-02-24

Other References: