Title:
3-DEOXY-DESMYCOSIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO2000066602
Kind Code:
A9
Abstract:
The present invention relates to derivatives of 3-deoxy desmycosin of formula (I), wherein, starting from triply protected desmycosin, there are performed an oxidation at C-3 in the first step and then, optionally, a hydrogenation of double bonds and an epoxidation followed by a reductive opening of the oxirane ring. The present invention also relates to derivatives of 3-deoxy-desmycosin of formula II, wherein in the first step triacetyl desmycosin is hydrogenated and then, via an intermediate mesylate, it is converted to a 2,3-didehydro derivative; or 2,3-didehydro-desmycosin is subjected to epoxidation reactions followed by a reductive opening of the oxirane ring.
Inventors:
NARANDJA AMALIJA (HR)
LOPOTAR NEVENKA (HR)
DJEREK MARKO (HR)
PAVLOVIC DRAZEN (HR)
LOPOTAR NEVENKA (HR)
DJEREK MARKO (HR)
PAVLOVIC DRAZEN (HR)
Application Number:
PCT/HR2000/000012
Publication Date:
December 20, 2001
Filing Date:
May 02, 2000
Export Citation:
Assignee:
PLIVA FARMACEUTSKA IND DIONIICKO DRUSTRO (HR)
NARANDJA AMALIJA (HR)
LOPOTAR NEVENKA (HR)
DJEREK MARKO (HR)
PAVLOVIC DRAZEN (HR)
NARANDJA AMALIJA (HR)
LOPOTAR NEVENKA (HR)
DJEREK MARKO (HR)
PAVLOVIC DRAZEN (HR)
International Classes:
A61K31/70; A61K31/7048; A61P31/00; A61P31/04; C07D305/00; C07D321/00; C07H17/08; A61K; A61P; C07H; (IPC1-7): C07H17/08; A61K31/70; A61P31/04
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