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Title:
3-HYDROXY-5-PREGNANE-20-ONE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/027744
Kind Code:
A1
Abstract:
Provided in the present invention are a 3-hydroxy-5-pregnane-20-one derivative as shown in formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the derivative or the pharmaceutically acceptable salt thereof. The derivative or the pharmaceutically acceptable salt thereof or the pharmaceutical composition comprising the above-mentioned derivative or salt of the present invention can be used to prepare a drug for treating a disease caused by abnormalities in the central nervous system.

Inventors:
LIU FEI (CN)
WU GANG (CN)
LIN CHENGGANG (CN)
WANG XIAOBO (CN)
WANG XIAOQIANG (CN)
WANG RUZHI (CN)
ZHU BIN (CN)
XU KONGCHAO (CN)
SUN XIAOYAN (CN)
CAI JUN (CN)
WANG LIN (CN)
JIANG WEIHUA (CN)
ZHENG MINQIANG (CN)
Application Number:
PCT/CN2020/107965
Publication Date:
February 18, 2021
Filing Date:
August 07, 2020
Export Citation:
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Assignee:
NANJING NORATECH PHARMACEUTICALS CO LTD (CN)
International Classes:
C07J7/00; A61K31/57; A61K31/58; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30
Domestic Patent References:
WO2009108804A22009-09-03
WO2011120044A12011-09-29
WO2015081170A22015-06-04
WO2010088409A22010-08-05
Foreign References:
CN108148106A2018-06-12
CN108517001A2018-09-11
CN102753181A2012-10-24
US20140005132A12014-01-02
CN101585862A2009-11-25
CN109776647A2019-05-21
CN103772469A2014-05-07
Other References:
JIHUA LIU, JINPING LIU, DAN LU, PINGYA LI, YING WANG: "The Synthesis of 20(S)-Protopanaxadiol Amino Acid Derivatives", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, CHINESE PHARMACEUTICAL ASSOCIATION, CN, vol. 27, no. 20, 1 January 2010 (2010-01-01), CN, pages 916 - 920, XP055779662, ISSN: 1007-7693, DOI: 10.13748/j.cnki.issn1007-7693.2010.10.011
J.D. COCKER, J. ELKS, P.J. MAY, F.A. NICE, G.H. PHILLIPPS, W.F. WALL: "Action of Some Steroids on the Central Nervous System of the Mouse. I. Synthetic Methods", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 8, no. 4, 1 July 1965 (1965-07-01), US, pages 417 - 425, XP002619548, ISSN: 0022-2623, DOI: 10.1021/jm00328a003
BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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