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Patent Searching and Data


Title:
3-(NAPHTHALENE-1-METHYL SUBSTITUTED)PYRIDINE DERIVATIVE, SYNTHETIC METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/169890
Kind Code:
A1
Abstract:
Disclosed in the present invention are a 3-(naphthalene-1-methyl substituted)pyridine derivative, a synthetic method therefor and use thereof. Said derivative has a structural general formula of (I). The compound having the structure or a pharmaceutically acceptable salt, a hydrate, a solvate, a polymorph, a tautomer, a stereoisomer or a pro-drug thereof has higher hURAT1 inhibitory activity, and has stronger inhibitory activity on the transport of uric acid by MDCK-hURAT1 cells, and thus can be used to prepare a medicament for the treatment and/or prevention and/or retardation and/or adjuvant treatment and/or processing of diseases associated with the transport of uric acid by hURAT1, particularly hyperuricemia. By combining with other medicaments for the treatment of hyperuricemia, it is expected to achieve better therapeutic effects on hyperuricemia.

Inventors:
ZHANG JIAJIE (CN)
TIAN YUANXIN (CN)
PANG JIANXIN (CN)
Application Number:
PCT/CN2018/115184
Publication Date:
September 12, 2019
Filing Date:
November 13, 2018
Export Citation:
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Assignee:
UNIV SOUTHERN MEDICAL (CN)
International Classes:
C07D213/61; A61K31/44; A61P19/06; C07D213/30; C07D213/55; C07D213/68; C07D213/70; C07D213/73; C07D213/74
Foreign References:
CN103068801A2013-04-24
CN106831556A2017-06-13
CN105439946A2016-03-30
Other References:
CAI, WENQING: "Systematic structure-activity relationship (SAR) exploration of diarylmethane backbone and discovery of a highly potent novel uric acid transporter 1 (URAT1) inhibitor", MOLECULES, vol. 23, no. 2, 27 January 2018 (2018-01-27), pages e252, XP055637690, ISSN: 1420-3049
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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