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Title:
32244, A NOVEL HUMAN AMP-BINDING ENZYME AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2001090322
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acids molecules, designated 32244 nucleic acid molecules, which encode novel AMP-binding enzyme members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32244 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32244 gene has been introduced or disrupted. The invention still further provides isolated 32244 proteins, fusion proteins, antigenic peptides and anti-32244 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Inventors:
MEYERS RACHEL A (US)
Application Number:
PCT/US2001/016292
Publication Date:
June 13, 2002
Filing Date:
May 18, 2001
Export Citation:
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Assignee:
MILLENNIUM PHARM INC (US)
MEYERS RACHEL A (US)
International Classes:
C07K14/47; (IPC1-7): C12N9/00; C07K14/47; C07K16/18; C12N5/10; C12Q1/68
Domestic Patent References:
WO2000058473A22000-10-05
Foreign References:
EP1067182A22001-01-10
Other References:
DATABASE EMBL [online] 30 June 1999 (1999-06-30), XP002190768, retrieved from EBI accession no. AC007905
DATABASE EMBL [online] 14 September 1999 (1999-09-14), XP002190769, retrieved from EBI accession no. AW025904
TOMODA H ET AL: "EVIDENCE FOR AN ESSENTIAL ROLE OF LONG CHAIN ACYL-COENZYME A SYNTHETASE IN ANIMAL CELL PROLIFERATION INHIBITION OF LONG CHAIN ACYL-COENZYME A SYNTHETASE BY TRIACSINS CAUSED INHIBITION OF RAJI CELL PROLIFERATION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 7, 1991, pages 4214 - 4219, XP002190767, ISSN: 0021-9258
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