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Title:
46638, A PUTATIVE FAMILY MEMBER OF HUMAN LIPOXYGENASE
Document Type and Number:
WIPO Patent Application WO2001090323
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acids molecules, designated 46638 nucleic acid molecules, which encode novel lipoxygenase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 46638 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 46638 gene has been introduced or disrupted. The invention still further provides isolated 46638 proteins, fusion proteins, antigenic peptides and anti-46638 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Inventors:
MEYERS RACHEL A (US)
Application Number:
PCT/US2001/016380
Publication Date:
July 18, 2002
Filing Date:
May 21, 2001
Export Citation:
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Assignee:
MILLENNIUM PHARM INC (US)
MEYERS RACHEL A (US)
International Classes:
C12N9/02; C12N15/53; (IPC1-7): C12N9/02; C07K16/40; C12N15/53
Domestic Patent References:
WO1999013111A11999-03-18
WO2000061765A22000-10-19
WO2001085956A22001-11-15
Other References:
KINZIG ANDREAS ET AL: "cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase.", GENOMICS, vol. 58, no. 2, 1 June 1999 (1999-06-01), pages 158 - 164, XP002189982, ISSN: 0888-7543
BOEGLIN W ET AL: "A 12R-lipoxygenase in human skin: Mechanistic evidence, molecular cloning, and expression", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, June 1998 (1998-06-01), pages 6744 - 6749, XP002143911, ISSN: 0027-8424
BOADO R ET AL: "Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, 1992, pages 9044 - 9048, XP002143913, ISSN: 0027-8424
ROUZER C A ET AL: "CHARACTERIZATION OF CLONED HUMAN LEUKOCYTE 5 LIPOXYGENASE EXPRESSED IN MAMMALIAN CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,, US, vol. 263, no. 21, 1988, pages 10135 - 10140, XP002143912, ISSN: 0021-9258
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