5'-AMINOCARBONYL-PHOSPHONATES D4T INHIBITORS FOR REPRODUCING HUMAN IMMUNODEFICIENCY VIRUS

WIPO Patent Application WO/2004/111071

A1

The invention relates to molecular biology, virology and medicine, namely to the use of novel derivatives of 2'3'-didezoxi-2'3'-didehydrothymidine (d4T)-aminocarbonyl-phosphonates of general formula (I), wherein R'=H, alkyl, aryl, R''=H, alkyl, aryl; R', R''=cyclyi alkyl, R=alkyl, in the form of HIV inhibitors. In particular, said compounds exhibit the ability to suppress the reproduction of a type-one human immunodeficiency virus in a passage culture of MT-4 lymphocytes. The anti-viral activity of the inventive novel compounds is higher than the d4T activity with respect to HIV.

POKROVSKY ANDREI GEORGIEVICH (RU)
PRONYAEVA TATYANA RUDOLFOVNA (RU)
FEDYUK NINA VLADIMIROVNA (RU)
KUKHANOVA MARINA KONSTANTINOVN (RU)
SHIROKOVA ELENA ANATOLEVNA (RU)
YASKO MAKSIM VLADIMIROVICH (RU)
KHANDAZHINSKAYA ANASTASIA LVOV (RU)
YANVAREV DMITRY VASILEVICH (RU)

PCT/RU2003/000513

December 23, 2004

November 21, 2003

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G NAUCHNY TS VIRUSOLOGII I BIO (RU)
INST MOLEKULYARNOY BIOLOG IM V (RU)
POKROVSKY ANDREI GEORGIEVICH (RU)
PRONYAEVA TATYANA RUDOLFOVNA (RU)
FEDYUK NINA VLADIMIROVNA (RU)
KUKHANOVA MARINA KONSTANTINOVN (RU)
SHIROKOVA ELENA ANATOLEVNA (RU)
YASKO MAKSIM VLADIMIROVICH (RU)
KHANDAZHINSKAYA ANASTASIA LVOV (RU)
YANVAREV DMITRY VASILEVICH (RU)

C07H19/20; A61K31/711; A61P31/18; A61P37/00; C07H19/10; (IPC1-7): C07H19/10; A61K31/7064; A61P37/00

RU2188203C2	2002-08-27
EP0306597A2	1989-03-15
RU2130942C1	1999-05-27

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