Title:
5-AZIDO-LAEVULINIC ACID, METHOD FOR THE PRODUCTION THEREOF AND ITS USE
Document Type and Number:
WIPO Patent Application WO2002053532
Kind Code:
A3
Abstract:
The invention relates to 5-azido-laevulinic acid, to a method for the production thereof and to its use. By using 5-azido-laevulinic acid as an educt for the synthesis of 5-aminolaevulinic acid hydrochloride, it is possible to produce this compound with favorable yields and with pharmaceutical quality. To this end, 5-azido-laevulinic acid is produced by reacting 5-bromolaevulinic acid methyl ester and/or 5-chlorolaevulinic acid methyl ester with aqueous hydrochloric acid, and a mixture consisting of 5-chlorolaevulinic acid and of 5-bromolaevulinic acid is obtained as a result of an incomplete bromine/chlorine exchange. The obtained 5-chlorolaevulinic acid, a mixture consisting of 5-chlorolaevulinic acid and of 5-bromolaevulinic acid, and the pure 5-bromolaevulinic acid are converted into 5-azido-laevulinic acid by reacting them with an appropriate nucleophilic acid.
Inventors:
ALDENKORTT SVEN (DE)
Application Number:
PCT/DE2002/000074
Publication Date:
March 13, 2003
Filing Date:
January 08, 2002
Export Citation:
Assignee:
ALDENKORTT SVEN (DE)
International Classes:
C06B43/00; C06C7/00; C06D5/06; C07C227/04; C07C247/04; C07C229/22; (IPC1-7): C07C247/12; C07C227/04; C06B49/00
Foreign References:
| EP0845457A1 | 1998-06-03 | |||
| US5907058A | 1999-05-25 |
Other References:
HA H-J ET AL: "SELECTIVE BROMINATION OF KETONES. A CONVENIENT SYNTHESIS OF 5-AMINOLEVULINIC ACID", SYNTHETIC COMMUNICATIONS, MARCEL DEKKER, INC., BASEL, CH, vol. 24, no. 18, 1994, pages 2557 - 2562, XP008008563, ISSN: 0039-7911
Download PDF:
Previous Patent: METHYL PROPYL KETONE PEROXIDE FORMULATIONS AND THEIR USE FOR CURING UNSATURATED POLYESTERS
Next Patent: KAPPA OPIOID RECEPTOR LIGANDS
Next Patent: KAPPA OPIOID RECEPTOR LIGANDS